Novel experimental and analysis strategies for fast voltammetry: 2. A troubleshoot-free flow cell for FSCV calibrations
File(s)
Published version
Author(s)
Hexter, Melissa
van Batenburg-Sherwood, Joseph
Hashemi, Parastoo
Type
Journal Article
Abstract
Fast scan cyclic voltammetry (FSCV) at carbon fiber microelectrodes (CFMs) is a method traditionally used for real-time quantification of neurotransmitters in biological systems. Reliable calibration of CFMs is essential for converting FSCV signals to analyte concentrations and generally employs flow injection analysis (FIA) performed with flow cells fabricated in-house. Such FSCV FIA cells often require significant and ongoing troubleshooting with pulsing, leaking, flow inconsistencies and dead volume being major causes of common challenges. In this work, we address these issues by creating a robust, plug-and-play FSCV flow cell. This novel design permits reproducible, high-precision, and stable flow injection profiles using low-cost materials to improve FSCV calibration. The ready-to-print computer-aided designs and hardware list are provided.
Date Issued
2023-04-19
Date Acceptance
2022-12-02
Citation
ACS Measurement Science Au, 2023, 3 (2), pp.120-126
ISSN
2694-250X
Publisher
American Chemical Society (ACS)
Start Page
120
End Page
126
Journal / Book Title
ACS Measurement Science Au
Volume
3
Issue
2
Copyright Statement
© 2023 The Authors. Published by American Chemical Society. This work is published under a CC BY licence.
License URL
Identifier
https://pubs.acs.org/doi/10.1021/acsmeasuresciau.2c00059
Publication Status
Published
Date Publish Online
2023-01-11