HIV-1 DNA predicts disease progression and post-treatment virological control.
File(s)
Author(s)
Type
Journal Article
Abstract
In HIV-1 infection, a population of latently infected cells facilitates viral persistence despite antiretroviral therapy (ART). With the aim of identifying individuals in whom ART might induce a period of viraemic control on stopping therapy, we hypothesised that quantification of the pool of latently infected cells in primary HIV-1 infection (PHI) would predict clinical progression and viral replication following ART. We measured HIV-1 DNA in a highly characterised randomised population of individuals with PHI. We explored associations between HIV-1 DNA and immunological and virological markers of clinical progression, including viral rebound in those interrupting therapy. In multivariable analyses, HIV-1 DNA was more predictive of disease progression than plasma viral load and, at treatment interruption, predicted time to plasma virus rebound. HIV-1 DNA may help identify individuals who could safely interrupt ART in future HIV-1 eradication trials.
Date Issued
2014-09-12
Date Acceptance
2014-09-04
Citation
eLife, 2014, 3, pp.1-16
ISSN
2050-084X
Publisher
eLife Sciences Publications Ltd
Start Page
1
End Page
16
Journal / Book Title
eLife
Volume
3
Copyright Statement
© Copyright Williams et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Sponsor
Wellcome Trust
National Institute for Health Research
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000341775900003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Grant Number
069598/Z/02/Z
NF-SI-0507-10313
Subjects
Science & Technology
Life Sciences & Biomedicine
Biology
Life Sciences & Biomedicine - Other Topics
ANTIRETROVIRAL THERAPY
LATENT RESERVOIR
INFECTION
VIREMIA
INTERRUPTION
VIRUS
LEVEL
CELLS
TIME
CESSATION
Publication Status
Published
Article Number
ARTN e03821
Date Publish Online
2014-09-12