Association of adult lung function with accelerated biological aging
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Supplementary information
Published version
Author(s)
Type
Journal Article
Abstract
Lung function, strongly associated with morbidity and mortality, decreases with age. This study examines whether poor adult lung function is associated with age accelerations (AAs). DNA methylation (DNAm) based AAs, lifespan predictors (GrimAge and plasminogen activator inhibitor 1-PAI1) and their related age-adjusted measures were estimated from peripheral blood at two time points (8-to-11 years apart) in adults from two cohorts: SAPALDIA (n=987) and ECRHS (n=509). Within each cohort and stratified by gender (except for estimators from GrimAge and PAI1), AAs were used as predictors in multivariate linear regression with cross-sectional lung function parameters, and in covariate-adjusted mixed linear regression with longitudinal change in lung function and meta-analysed.
AAs were found cross-sectionally associated with lower mean FEV1 (Forced Expiratory Volume in one second) (AA-residuals:P-value=4x10-4; Intrinsic Epigenetic AA:P-value=2x10-4) in females at the follow-up time point only, and the same trend was observed for FVC (Forced Vital Capacity). Both lifespan and plasma level predictors were observed strongly associated with lung function decline and the decline was stronger in the follow-up time points (strongest association between FEV1 and DNAmAge GrimAge:P-value=1.25x10-17).
This study suggests that DNAm based lifespan and plasma level predictors can be utilised as important factors to assess lung health in adults.
AAs were found cross-sectionally associated with lower mean FEV1 (Forced Expiratory Volume in one second) (AA-residuals:P-value=4x10-4; Intrinsic Epigenetic AA:P-value=2x10-4) in females at the follow-up time point only, and the same trend was observed for FVC (Forced Vital Capacity). Both lifespan and plasma level predictors were observed strongly associated with lung function decline and the decline was stronger in the follow-up time points (strongest association between FEV1 and DNAmAge GrimAge:P-value=1.25x10-17).
This study suggests that DNAm based lifespan and plasma level predictors can be utilised as important factors to assess lung health in adults.
Date Issued
2020-01-11
Date Acceptance
2019-12-21
Citation
Aging-US, 2020, 12 (1), pp.518-542
ISSN
1945-4589
Publisher
Impact Journals
Start Page
518
End Page
542
Journal / Book Title
Aging-US
Volume
12
Issue
1
Copyright Statement
© 2020 Rezwan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Sponsor
Commission of the European Communities
Grant Number
633212
Subjects
Science & Technology
Life Sciences & Biomedicine
Cell Biology
Geriatrics & Gerontology
respiratory health
lung function
epigenetic clock
DNA methylation
age acceleration
DNA METHYLATION AGE
EPIGENETIC AGE
AIR-POLLUTION
COHORT
BLOOD
MENOPAUSE
DECLINE
CLOCK
SWISS
DNA methylation
age acceleration
epigenetic clock
lung function
respiratory health
0601 Biochemistry and Cell Biology
0606 Physiology
1112 Oncology and Carcinogenesis
Publication Status
Published