Hypertension in stroke survivors and associations with national premature stroke mortality: data on 2.5 million participants from multinational screening campaigns.
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Published version
Author(s)
Type
Journal Article
Abstract
Background
Blood pressure (BP) control plays a pivotal role in reducing stroke incidence and recurrence. May Measurement Month (MMM) is the largest global BP screening campaign, initiated in 2017 by the International Society of Hypertension (ISH). We aim to compare MMM participants with and without a previous stroke and to investigate associations between national-level estimates of BP management from MMM and premature stroke mortality.
Methods
Over 2.5 million volunteers (≥18 years) were screened in May 2017 and 2018 from 92 countries. Three seated BPs and demographic, lifestyle, and cardiovascular disease data were collected. Associations between risk factors and stroke history were analysed using mixed-effects logistic regression. Linear regression was used to investigate associations between national-level estimates of BP management and premature stroke mortality based on Global Burden of Diseases (GBD) data.
Findings
Of 2 222 399 (88·4%) participants with recorded data on a history of stroke, 62 639 (2·8%) reported a previous stroke. Those with a stroke history had higher rates of hypertension and treated and controlled hypertension than those without. One third of those with a stroke history had untreated or treated but uncontrolled BP (≥140/90 mmHg). Strong positive associations were found between national premature stroke mortality and increasing mean systolic BP levels and proportion of participants with raised BP and strong negative associations with the proportions of hypertensives on treatment and with controlled BP.
Interpretation
BP control remains suboptimal worldwide amongst those with a previous stroke. National estimates of BP management reflect national premature stroke mortality sufficiently well to provide a prompt for policymakers to promote BP screening and management.
Blood pressure (BP) control plays a pivotal role in reducing stroke incidence and recurrence. May Measurement Month (MMM) is the largest global BP screening campaign, initiated in 2017 by the International Society of Hypertension (ISH). We aim to compare MMM participants with and without a previous stroke and to investigate associations between national-level estimates of BP management from MMM and premature stroke mortality.
Methods
Over 2.5 million volunteers (≥18 years) were screened in May 2017 and 2018 from 92 countries. Three seated BPs and demographic, lifestyle, and cardiovascular disease data were collected. Associations between risk factors and stroke history were analysed using mixed-effects logistic regression. Linear regression was used to investigate associations between national-level estimates of BP management and premature stroke mortality based on Global Burden of Diseases (GBD) data.
Findings
Of 2 222 399 (88·4%) participants with recorded data on a history of stroke, 62 639 (2·8%) reported a previous stroke. Those with a stroke history had higher rates of hypertension and treated and controlled hypertension than those without. One third of those with a stroke history had untreated or treated but uncontrolled BP (≥140/90 mmHg). Strong positive associations were found between national premature stroke mortality and increasing mean systolic BP levels and proportion of participants with raised BP and strong negative associations with the proportions of hypertensives on treatment and with controlled BP.
Interpretation
BP control remains suboptimal worldwide amongst those with a previous stroke. National estimates of BP management reflect national premature stroke mortality sufficiently well to provide a prompt for policymakers to promote BP screening and management.
Date Issued
2022-08
Date Acceptance
2022-05-11
Citation
The Lancet Global Health, 2022, 10 (8), pp.e1141-e1149
ISSN
2214-109X
Publisher
Elsevier
Start Page
e1141
End Page
e1149
Journal / Book Title
The Lancet Global Health
Volume
10
Issue
8
Copyright Statement
© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0
license.
license.
License URL
Sponsor
National Institute for Health Research Applied Research Collaboration North West London
Identifier
https://www.sciencedirect.com/science/article/pii/S2214109X22002388?via%3Dihub
Subjects
Antihypertensive Agents
Cross-Sectional Studies
Humans
Hypertension
Stroke
Survivors
0605 Microbiology
1117 Public Health and Health Services
Publication Status
Published
Date Publish Online
2022-07-12