Localized and controlled delivery of nitric oxide to the conventional outflow pathway via enzyme biocatalysis: towards therapy for Glaucoma
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Nitric oxide (NO) has been shown to lower intraocular pressure (IOP), however its therapeutic effects on outflow physiology are location- and dose-dependent. Here, a NO delivery platform that directly targets the resistance-generating region of the conventional outflow pathway and locally liberates a controlled dose of NO is reported. An increase in outflow facility (decrease in IOP) is demonstrated in mouse model.
Date Issued
2017-04-25
Date Acceptance
2016-12-28
Citation
Advanced Materials, 2017, 29 (16)
ISSN
1521-4095
Publisher
Wiley
Journal / Book Title
Advanced Materials
Volume
29
Issue
16
Copyright Statement
© 2017 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
License URL
Sponsor
Commission of the European Communities
Commission of the European Communities
Wellcome Trust
Engineering & Physical Science Research Council (EPSRC)
Rosetrees Trust
Grant Number
PIIF-GA-2011-299936
ERC-2013-CoG-616417
098411/Z/12/Z
EP/K020641/1
M216
Subjects
Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Chemistry, Physical
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Physics, Applied
Physics, Condensed Matter
Chemistry
Science & Technology - Other Topics
Materials Science
Physics
OPEN-ANGLE GLAUCOMA
HUMAN TRABECULAR MESHWORK
AQUEOUS-HUMOR OUTFLOW
LATANOPROSTENE BUNOD 0.024-PERCENT
TIMOLOL MALEATE 0.5-PERCENT
OCULAR HYPERTENSION
INTRAOCULAR-PRESSURE
CILIARY MUSCLE
SYNTHASE GENE
CAPSULES
glaucoma
layer-by-layer capsules
liposomes
nitric oxide
β-galactosidase
Animals
Aqueous Humor
Biocatalysis
Glaucoma
Intraocular Pressure
Mice
Nitric Oxide
Aqueous Humor
Animals
Mice
Glaucoma
Nitric Oxide
Intraocular Pressure
Biocatalysis
Nanoscience & Nanotechnology
02 Physical Sciences
03 Chemical Sciences
09 Engineering
Publication Status
Published
Article Number
ARTN 1604932
Date Publish Online
2017-02-21