Iodo silanes as superior substrates for the solid phase synthesis of molecularly imprinted polymer nanoparticles
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Current state-of-the-art techniques for the solid phase synthesis of molecularly imprinted polymer (MIP) nanoparticles typically rely on amino silanes for the immobilisation of template molecules prior to polymerisation. An investigation into commonly used amino silanes identified a number of problematic side reactions which negatively affect the purity and affinity of these polymers. Iodo silanes are presented as a superior alternative in a case study describing the synthesis of MIPs against epitopes of a common cancer biomarker, epidermal growth factor receptor (EGFR). The proposed iodo silane outperformed the amino silane by all metrics tested, showing high purity and specificity, and nanomolar affinity for the target peptide.
Date Issued
2022-04-14
Date Acceptance
2022-04-12
Citation
Polymers, 2022, 14 (8), pp.1-8
ISSN
2073-4360
Publisher
MDPI AG
Start Page
1
End Page
8
Journal / Book Title
Polymers
Volume
14
Issue
8
Copyright Statement
© 2022 by the authors.
Licensee MDPI, Basel, Switzerland.
This article is an open access article
distributed under the terms and
conditions of the Creative Commons
Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Licensee MDPI, Basel, Switzerland.
This article is an open access article
distributed under the terms and
conditions of the Creative Commons
Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
License URL
Sponsor
Imperial College Healthcare NHS Trust- BRC Funding
Identifier
https://www.mdpi.com/2073-4360/14/8/1595
Grant Number
RDC04 79560
Subjects
Science & Technology
Physical Sciences
Polymer Science
molecularly imprinted polymers
solid phase synthesis
epidermal growth factor receptor
EXTRACTION
epidermal growth factor receptor
molecularly imprinted polymers
solid phase synthesis
03 Chemical Sciences
09 Engineering
Publication Status
Published
Date Publish Online
2022-04-14