Designing new natural‐Mimetic phosphatidic acid: a versatile and innovative synthetic strategy for glycerophospholipid research
Author(s)
Type
Journal Article
Abstract
<jats:title>Abstract</jats:title>
<jats:p>Glycerophospholipids (GPLs) play important roles in cellular compartmentalization and signaling. Among them, phosphatidic acids (PA) exist as many distinct species depending on acyl chain composition, each one potentially displaying unique signaling function. Although the signaling functions of PA have already been demonstrated in multiple cellular processes, the specific roles of individual PA species remain obscure due to a lack of appropriate tools. Indeed, current synthetic PA analogues fail to preserve all the functions of natural PA. To circumvent these limitations, we developed a novel synthetic approach to produce PA analogues without compromising structural integrity of acyl chains. Moreover, addition of a clickable moiety allowed flexible grafting of different molecules to PA analogues for various biological applications. Hence, this innovation also provides powerful tools to investigate specific biological activities of individual PA species, with potential applications in unraveling complex GPL‐mediated signaling pathways.</jats:p>
<jats:p>Glycerophospholipids (GPLs) play important roles in cellular compartmentalization and signaling. Among them, phosphatidic acids (PA) exist as many distinct species depending on acyl chain composition, each one potentially displaying unique signaling function. Although the signaling functions of PA have already been demonstrated in multiple cellular processes, the specific roles of individual PA species remain obscure due to a lack of appropriate tools. Indeed, current synthetic PA analogues fail to preserve all the functions of natural PA. To circumvent these limitations, we developed a novel synthetic approach to produce PA analogues without compromising structural integrity of acyl chains. Moreover, addition of a clickable moiety allowed flexible grafting of different molecules to PA analogues for various biological applications. Hence, this innovation also provides powerful tools to investigate specific biological activities of individual PA species, with potential applications in unraveling complex GPL‐mediated signaling pathways.</jats:p>
Date Issued
2025-09-01
Date Acceptance
2025-07-04
Citation
Angewandte Chemie International Edition, 2025, 64 (36)
ISSN
1433-7851
Publisher
Wiley
Start Page
e202510412
Journal / Book Title
Angewandte Chemie International Edition
Volume
64
Issue
36
Copyright Statement
© 2025 The Author(s). Angewandte Chemie International Edition published by Wiley-VCH GmbH.
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/40626950
Subjects
Click chemistry
Exocytosis
Phospholipids
Photolabelling
Probes design
Phosphatidic Acids
Glycerophospholipids
Humans
Molecular Structure
Signal Transduction
Publication Status
Published
Coverage Spatial
Germany
Article Number
e202510412
Date Publish Online
2025-07-25