Development of BOLD signal hemodynamic responses in the human brain
File(s)Arichi2012NI.pdf (1.11 MB)
Published version
Author(s)
Type
Journal Article
Abstract
In the rodent brain the hemodynamic response to a brief external stimulus changes significantly during development. Analogous changes in human infants would complicate the determination and use of the hemodynamic response function (HRF) for functional magnetic resonance imaging (fMRI) in developing populations. We aimed to characterize HRF in human infants before and after the normal time of birth using rapid sampling of the Blood Oxygen Level Dependent (BOLD) signal. A somatosensory stimulus and an event related experimental design were used to collect data from 10 healthy adults, 15 sedated infants at term corrected post menstrual age (PMA) (median 41 + 1 weeks), and 10 preterm infants (median PMA 34 + 4 weeks). A positive amplitude HRF waveform was identified across all subject groups, with a systematic maturational trend in terms of decreasing time-to-peak and increasing positive peak amplitude associated with increasing age. Application of the age-appropriate HRF models to fMRI data significantly improved the precision of the fMRI analysis. These findings support the notion of a structured development in the brain's response to stimuli across the last trimester of gestation and beyond.
Date Issued
2012-07-06
Online Publication Date
2012-07-06
2016-10-26T13:35:03Z
Date Acceptance
2012-06-21
ISSN
1095-9572
Publisher
Elsevier
Start Page
663
End Page
673
Journal / Book Title
Neuroimage
Volume
63
Issue
2
Copyright Statement
Open access under CC BY license.
Source Database
web-of-science
Subjects
Science & Technology
Life Sciences & Biomedicine
Neurosciences
Neuroimaging
Radiology, Nuclear Medicine & Medical Imaging
Neurosciences & Neurology
NEUROIMAGING
NEUROSCIENCES
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Brain development
Neonate
Functional MRI
Hemodynamic response function
CEREBRAL-BLOOD-FLOW
NEAR-INFRARED SPECTROSCOPY
EVENT-RELATED FMRI
FUNCTIONAL CONNECTIVITY MRI
RAT SOMATOSENSORY CORTEX
MAGNETIC-RESONANCE
CHLORAL HYDRATE
NEWBORN-INFANTS
POSTSTIMULUS UNDERSHOOT
SENSORY STIMULATION
Adult
Brain
Female
Hemodynamics
Humans
Image Interpretation, Computer-Assisted
Infant
Infant, Newborn
Infant, Premature
Magnetic Resonance Imaging
Male
Middle Aged
Oxygen
Young Adult
Neurology & Neurosurgery
11 Medical And Health Sciences
17 Psychology And Cognitive Sciences
Publication Status
Published