Modelling plasticity in dendrites: from single cells to networks
File(s)DendritesPlasticity_revision1_v_changed_ref.pdf (184.26 KB)
Accepted version
Author(s)
Bono, J
Wilmes, K
Clopath, C
Type
Journal Article
Abstract
One of the key questions in neuroscience is how our brain self-organises to efficiently process information. To answer this question, we need to understand the underlying mechanisms of plasticity and their role in shaping synaptic connectivity. Theoretical neuroscience typically investigates plasticity on the level of neural networks. Neural network models often consist of point neurons, completely neglecting neuronal morphology for reasons of simplicity. However, during the past decades it became increasingly clear that inputs are locally processed in the dendrites before they reach the cell body. Dendritic properties enable local interactions between synapses and location-dependent modulations of inputs, rendering the position of synapses on dendrites highly important. These insights changed our view of neurons, such that we now think of them as small networks of nearly independent subunits instead of a simple point. Here, we propose that understanding how the brain processes information strongly requires that we consider the following properties: which plasticity mechanisms are present in the dendrites and how do they enable the self-organisation of synapses across the dendritic tree for efficient information processing? Ultimately, dendritic plasticity mechanisms can be studied in networks of neurons with dendrites, possibly uncovering unknown mechanisms that shape the connectivity in our brains.
Date Issued
2017-09-08
Date Acceptance
2017-08-23
Citation
Current Opinion in Neurobiology, 2017, 46, pp.136-141
ISSN
0959-4388
Publisher
Elsevier
Start Page
136
End Page
141
Journal / Book Title
Current Opinion in Neurobiology
Volume
46
Copyright Statement
© 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor
Wellcome Trust
Grant Number
200790/Z/16/Z
Subjects
1109 Neurosciences
1702 Cognitive Science
Publication Status
Published