Robust formation of morphogen gradients
File(s)0412014v1.pdf (170.16 KB)
Accepted version
Author(s)
Bollenbach, T
Kruse, K
Pantazis, P
Gonzalez-Gaitan, M
Julicher, F
Type
Journal Article
Abstract
We discuss the formation of graded morphogen profiles in a cell layer by nonlinear transport phenomena, important for patterning developing organisms. We focus on a process termed transcytosis, where morphogen transport results from the binding of ligands to receptors on the cell surface, incorporation into the cell, and subsequent externalization. Starting from a microscopic model, we derive effective transport equations. We show that, in contrast to morphogen transport by extracellular diffusion, transcytosis leads to robust ligand profiles which are insensitive to the rate of ligand production.
Date Issued
2005-01-14
Date Acceptance
2004-07-12
Citation
PHYSICAL REVIEW LETTERS, 2005, 94 (1)
ISSN
0031-9007
Publisher
American Physical Society
Journal / Book Title
PHYSICAL REVIEW LETTERS
Volume
94
Issue
1
Copyright Statement
© 2005 American Physical Society
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000226308000088&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Physical Sciences
Physics, Multidisciplinary
Physics
BIOLOGICAL PATTERN-FORMATION
IMAGINAL DISC
DIFFUSION
DPP
TRAFFICKING
ENDOCYTOSIS
MECHANISMS
Publication Status
Published
Article Number
ARTN 018103
Date Publish Online
2005-01-06