An indocyanine green‐based nanoprobe for in vivo detection of cellular senescence
Author(s)
Type
Journal Article
Abstract
There is an urgent need to improve conventional cancer-treatments by preventing detrimental side effects, cancer recurrence and metastases. Recent studies have shown that presence of senescent cells in tissues treated with chemo- or radiotherapy can be used to predict the effectiveness of cancer treatment. However, although the accumulation of senescent cells is one of the hallmarks of cancer, surprisingly little progress has been made in development of strategies for their detection in vivo. To address a lack of detection tools, we developed a biocompatible, injectable organic nanoprobe (NanoJagg), which is selectively taken up by senescent cells and accumulates in the lysosomes. The NanoJagg probe is obtained by self-assembly of indocyanine green (ICG) dimers using a scalable manufacturing process and characterized by a unique spectral signature suitable for both photoacoustic tomography (PAT) and fluorescence imaging. In vitro, ex vivo and in vivo studies all indicate that NanoJaggs are a clinically translatable probe for detection of senescence and their PAT signal makes them suitable for longitudinal monitoring of the senescence burden in solid tumors after chemotherapy or radiotherapy.
Date Issued
2024-06-17
Date Acceptance
2024-04-01
Citation
Angewandte Chemie International Edition, 2024, 63 (25)
ISSN
1433-7851
Publisher
Wiley
Journal / Book Title
Angewandte Chemie International Edition
Volume
63
Issue
25
Copyright Statement
© 2024 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/38622059
Subjects
Cellular senescence
ICG nanoprobe
cancer
endocytosis
photoacoustic tomography (PAT)
Indocyanine Green
Cellular Senescence
Humans
Animals
Optical Imaging
Mice
Nanoparticles
Fluorescent Dyes
Photoacoustic Techniques
Publication Status
Published
Coverage Spatial
Germany
Article Number
e202404885
Date Publish Online
2024-04-15