Clinical translation of quantitative magnetic resonance imaging biomarkers - An overview and gap analysis of current practice
File(s)
Author(s)
Type
Journal Article
Abstract
PURPOSE: This overview of the current landscape of quantitative magnetic resonance imaging biomarkers (qMR IBs) aims to support the standardisation of academic IBs to assist their translation to clinical practice. METHODS: We used three complementary approaches to investigate qMR IB use and quality management practices within the UK: 1) a literature search of qMR and quality management terms during 2011-2015 and 2016-2020; 2) a database search for clinical research studies using qMR IBs during 2016-2020; and 3) a survey to ascertain the current availability and quality management practices for clinical MRI scanners and associated equipment at research institutions across the UK. RESULTS: The analysis showed increased use of all qMR methods between the periods 2011-2015 and 2016-2020 and diffusion-tensor MRI and volumetry to be popular methods. However, the "translation ratio" of journal articles to clinical research studies was higher for qMR methods that have evidence of clinical translation via a commercial route, such as fat fraction and T2 mapping. The number of journal articles citing quality management terms doubled between the periods 2011-2015 and 2016-2020; although, its proportion relative to all journal articles only increased by 3.0%. The survey suggested that quality assurance (QA) and quality control (QC) of data acquisition procedures are under-reported in the literature and that QA/QC of acquired data/data analysis are under-developed and lack consistency between institutions. CONCLUSIONS: We summarise current attempts to standardise and translate qMR IBs, and conclude by outlining the ideal quality management practices and providing a gap analysis between current practice and a metrological standard.
Date Issued
2022-09-01
Date Acceptance
2022-08-17
Citation
Physica Medica: an international journal devoted to the applications of physics to medicine and biology, 2022, 101, pp.165-182
ISSN
1120-1797
Publisher
Elsevier
Start Page
165
End Page
182
Journal / Book Title
Physica Medica: an international journal devoted to the applications of physics to medicine and biology
Volume
101
Copyright Statement
© 2022 Associazione Italiana di Fisica Medica e Sanitaria. Published by Elsevier Ltd. This is an open access article under the CC BY license
(http://creativecommons.org/licenses/by/4.0/)
(http://creativecommons.org/licenses/by/4.0/)
License URL
Sponsor
Cancer Research UK
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/36055125
PII: S1120-1797(22)02039-7
Grant Number
28680
Subjects
Clinical translation
Metrology
QAQC
Quantitative MRI
Biomarkers
Body Composition
Diffusion Tensor Imaging
Humans
Irritable Bowel Syndrome
Magnetic Resonance Imaging
Publication Status
Published
Coverage Spatial
Italy
Date Publish Online
2022-08-30