Contemporary management of locally advanced and recurrent rectal cancer: views from the PelvEx collaborative
Author(s)
Kelly, Michael Eamon
Type
Journal Article
Abstract
Pelvic exenteration is a complex operation performed for locally advanced and recurrent pelvic cancers. The goal of surgery is to achieve clear margins, therefore identifying adjacent or involved organs, bone, muscle, nerves and/or vascular structures that may need resection. While these extensive resections are potentially curative, they can be associated with substantial morbidity. Recently, there has been a move to centralize care to specialized units, as this facilitates better multidisciplinary care input. Advancements in pelvic oncology and surgical innovation have redefined the boundaries of pelvic exenterative surgery. Combined with improved neoadjuvant therapies, advances in diagnostics, and better reconstructive techniques have provided quicker recovery and better quality of life outcomes, with improved survival This article provides highlights of the current management of advanced pelvic cancers in terms of surgical strategy and potential future developments
Date Issued
2022-03-01
Date Acceptance
2022-02-21
Citation
Cancers, 2022, 14 (5)
ISSN
2072-6694
Publisher
MDPI AG
Journal / Book Title
Cancers
Volume
14
Issue
5
Copyright Statement
© 2022 by the author.
Licensee MDPI, Basel, Switzerland.
This article is an open access article
distributed under the terms and
conditions of the Creative Commons
Attribution (CC BY) license (https://
creativecommons.org/licenses/by/
4.0/).
Licensee MDPI, Basel, Switzerland.
This article is an open access article
distributed under the terms and
conditions of the Creative Commons
Attribution (CC BY) license (https://
creativecommons.org/licenses/by/
4.0/).
License URL
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000768331400001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Oncology
rectal cancer
locally advanced rectal cancer
recurrent rectal cancer
diagnostics
surgical management
surgical outcomes
perioperative care
quality of life
PATHOLOGICAL COMPLETE RESPONSE
HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY
QUALITY-OF-LIFE
WHOLE-BODY MRI
SURGICAL TECHNIQUES
NEOADJUVANT CHEMORADIOTHERAPY
CYTOREDUCTIVE SURGERY
ENHANCED RECOVERY
EXENTERATION
OUTCOMES
Publication Status
Published
Article Number
ARTN 1161