Senescent cells: emerging targets for human aging and age-related diseases
File(s)TIBS-D-19-00243_R2 (for Eric).pdf (765.06 KB)
Accepted version
Author(s)
Song, S
Lam, E
Tchkonia, T
Kirkland, JL
Sun, Y
Type
Journal Article
Abstract
Aging is a major risk factor for numerous human pathologies, including cardiovascular, metabolic, musculoskeletal, and neurodegenerative conditions and various malignancies. While our understanding of aging is far from complete, recent advances suggest that targeting fundamental aging processes can delay, prevent, or alleviate age-related disorders. Cellular senescence is physiologically beneficial in several contexts, but it has causal roles in multiple chronic diseases. New studies have illustrated the promising feasibility and safety to selectively ablate senescent cells from tissues, a therapeutic modality that holds potential for treating multiple chronic pathologies and extending human healthspan. Here, we review molecular links between cellular senescence and age-associated complications and highlight novel therapeutic avenues that may be exploited to target senescent cells in future geriatric medicine.
Date Issued
2020-07
Online Publication Date
2021-04-06T23:01:17Z
Date Acceptance
2020-04-06
ISSN
0167-7640
Publisher
Elsevier
Start Page
578
End Page
592
Journal / Book Title
Trends in Biochemical Sciences
Volume
45
Issue
7
Copyright Statement
© 2020 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor
Cancer Research UK
Breast Cancer Care & Breast Cancer Now
Breast Cancer Care & Breast Cancer Now
Medical Research Council (MRC)
Identifier
https://www.sciencedirect.com/science/article/pii/S0968000420300852?via%3Dihub
Grant Number
12011
2012NovemberPhD016
2012MayPR070
MR/N012097/1
Subjects
SASP
cellular senescence
clinical trials
geroscience
senolytics
Developmental Biology
03 Chemical Sciences
06 Biological Sciences
11 Medical and Health Sciences
Publication Status
Published
Date Publish Online
2020-04-06