Interleukin-18 Is Associated With Protection Against Rhinovirus-Induced Colds and Asthma Exacerbations
File(s)CIC_Jackson final.docx (52.73 KB)
Accepted version
Author(s)
Type
Journal Article
Abstract
Rhinoviruses cause the common cold and exacerbations of asthma. Animal models of infection have identified a protective role for interleukin-18 (IL-18). Following experimental rhinovirus infection, we observed increased respiratory symptoms in healthy and asthmatic subjects with low nasal and bronchial IL-18 levels.
Date Issued
2015-05-15
Date Acceptance
2015-01-13
Citation
Clinical Infectious Diseases, 2015, 60 (10), pp.1528-1531
ISSN
1537-6591
Publisher
Oxford University Press (OUP)
Start Page
1528
End Page
1531
Journal / Book Title
Clinical Infectious Diseases
Volume
60
Issue
10
Copyright Statement
© The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com. This is a pre-copyedited, author-produced PDF of an article accepted for publication in Clinical Infectious Diseases following peer review. The version of record Clin Infect Dis. (2015) 60 (10): 1528-1531. is available online at: https://dx.doi.org/10.1093/cid/civ062
Sponsor
Medical Research Council (MRC)
Grant Number
G1000758
Subjects
Science & Technology
Life Sciences & Biomedicine
Immunology
Infectious Diseases
Microbiology
interleukin-18
inflammasome
rhinovirus infection
asthma
VIRUS-INFECTION
IN-VIVO
CELLS
Publication Status
Published