Linkage of cDNA expression profiles of mesencephalic dopaminergic neurons to a genome-wide in situ hybridization database
Author(s)
Alavian, Kambiz N
Simon, Horst H
Type
Journal Article
Abstract
Midbrain dopaminergic neurons are involved in control of emotion, motivation and motor behavior. The loss of one of the subpopulations, substantia nigra pars compacta, is the pathological hallmark of one of the most prominent neurological disorders, Parkinson's disease. Several groups have looked at the molecular identity of midbrain dopaminergic neurons and have suggested the gene expression profile of these neurons. Here, after determining the efficiency of each screen, we provide a linked database of the genes, expressed in this neuronal population, by combining and comparing the results of six previous studies and verification of expression of each gene in dopaminergic neurons, using the collection of in situ hybridization in the Allen Brain Atlas.
Date Issued
2009-01-29
Date Acceptance
2009-01-29
Citation
Molecular Neurodegeneration, 2009, 4, pp.1-4
ISSN
1750-1326
Publisher
BMC
Start Page
1
End Page
4
Journal / Book Title
Molecular Neurodegeneration
Volume
4
Copyright Statement
© 2009 Alavian and Simon; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
License URL
Identifier
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000266063900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
FATE
GENE-EXPRESSION
Life Sciences & Biomedicine
MOUSE-BRAIN
Neurosciences
Neurosciences & Neurology
Science & Technology
SUBSTANTIA-NIGRA
TRANSCRIPTION FACTORS
VULNERABILITY
Publication Status
Published
Article Number
ARTN 6
Date Publish Online
2009-01-29