During future long-duration space exploration missions, humans will be exposed to combinations of extreme physical, psychological,
and interpersonal demands. These demands create risks for the safety, performance, health, and well-being of both individuals
and crew. The communication latency in deep space means that explorers will increasingly have to operate independently and
take responsibility for their own self-care and self-management. At present, several research programs are focused on developing
and testing digital technologies and countermeasures that support the effective functioning of deep space crews. Although
promising, these initiatives have been stimulated mostly by technological opportunity rather than cogent theory. In this perspective,
we argue that digital technologies developed for spaceflight should be informed by well-being–supportive design principles and
be cognizant of broader conversations around the development and use of digital health applications, especially pertaining to
issues of autonomy, privacy, and trust. These issues are important for designing potentially mission-critical health technologies
and may be determining factors in the safe and successful completion of future off-world endeavors.