The relationship between blood pressure and risk of renal cell carcinoma
File(s)
Author(s)
Type
Journal Article
Abstract
Background The relation between blood pressure and kidney cancer risk is well established but complex and different study designs have reported discrepant findings on the relative importance of diastolic blood pressure (DBP) and systolic blood pressure (SBP). In this study, we sought to describe the temporal relation between diastolic and SBP with renal cell carcinoma (RCC) risk in detail. Methods Our study involved two prospective cohorts: the European Prospective Investigation into Cancer and Nutrition study and UK Biobank, including >700 000 participants and 1692 incident RCC cases. Risk analyses were conducted using flexible parametric survival models for DBP and SBP both separately as well as with mutuality adjustment and then adjustment for extended risk factors. We also carried out univariable and multivariable Mendelian randomization (MR) analyses (DBP: ninstruments = 251, SBP: ninstruments = 213) to complement the analyses of measured DBP and SBP. Results In the univariable analysis, we observed clear positive associations with RCC risk for both diastolic and SBP when measured ≥5 years before diagnosis and suggestive evidence for a stronger risk association in the year leading up to diagnosis. In mutually adjusted analysis, the long-term risk association of DBP remained, with a hazard ratio (HR) per standard deviation increment 10 years before diagnosis (HR10y) of 1.20 (95% CI: 1.10–1.30), whereas the association of SBP was attenuated (HR10y: 1.00, 95% CI: 0.91–1.10). In the complementary multivariable MR analysis, we observed an odds ratio for a 1-SD increment (ORsd) of 1.34 (95% CI: 1.08–1.67) for genetically predicted DBP and 0.70 (95% CI: 0.56–0.88) for genetically predicted SBP. Conclusion The results of this observational and MR study are consistent with an important role of DBP in RCC aetiology. The relation between SBP and RCC risk was less clear but does not appear to be independent of DBP.
Date Issued
2022-03-21
Online Publication Date
2022-11-25T15:24:08Z
Date Acceptance
2022-03-07
ISSN
0300-5771
Publisher
Oxford University Press
Start Page
1317
End Page
1327
Journal / Book Title
International Journal of Epidemiology
Volume
51
Issue
4
Copyright Statement
© World Health Organization, 2022. All rights reserved. The World Health Organization has granted the Publisher permission for the reproduction of this article.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 IGO License (https://creativecommons.org/licenses/by/3.0/igo/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 IGO License (https://creativecommons.org/licenses/by/3.0/igo/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Sponsor
Cancer Research UK
Cancer Research UK
Cancer Research UK
Identifier
http://academic.oup.com/ije/article/51/4/1317/6551537?login=true
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000771149900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Grant Number
C57955/A24390
24390
PPRCPJT\100020
Subjects
Science & Technology
Life Sciences & Biomedicine
Public, Environmental & Occupational Health
RCC
diastolic blood pressure
systolic blood pressure
Mendelian randomization
kidney cancer
BODY-MASS INDEX
MENDELIAN RANDOMIZATION
KIDNEY CANCER
HYPERTENSION
MODELS
ASSOCIATION
INSTRUMENTS
COHORT
BIAS
MEN
Mendelian randomization
RCC
diastolic blood pressure
kidney cancer
systolic blood pressure
Blood Pressure
Carcinoma, Renal Cell
Humans
Hypertension
Kidney Neoplasms
Prospective Studies
Risk Factors
Humans
Carcinoma, Renal Cell
Kidney Neoplasms
Hypertension
Risk Factors
Prospective Studies
Blood Pressure
Science & Technology
Life Sciences & Biomedicine
Public, Environmental & Occupational Health
RCC
diastolic blood pressure
systolic blood pressure
Mendelian randomization
kidney cancer
BODY-MASS INDEX
MENDELIAN RANDOMIZATION
KIDNEY CANCER
HYPERTENSION
MODELS
ASSOCIATION
INSTRUMENTS
COHORT
BIAS
MEN
Epidemiology
0104 Statistics
1117 Public Health and Health Services
Publication Status
Published
Date Publish Online
2022-03-21