A search for the Ξ++cc baryon through the Ξ++cc→ D+pK−π+ decay is performed with a data sample corresponding to an integrated luminosity of 1.7 fb−1 recorded by the LHCb experiment in pp collisions at a centre-of-mass energy of 13 TeV. No significant signal is observed in the mass range from the kinematic threshold of the decay to 3800 MeV/c2. An upper limit is set on the ratio of branching fractions R=B(Ξ++cc→D+pK−π+)B(Ξ++cc→Λ+cK−π+π+) with ℛ < 1.7 (2.1) × 10−2 at the 90% (95%) confidence level at the known mass of the Ξ++cc state.A search for the Ξ++cc baryon through the Ξ++cc→ D+pK−π+ decay is performed with a data sample corresponding to an integrated luminosity of 1.7 fb−1 recorded by the LHCb experiment in pp collisions at a centre-of-mass energy of 13 TeV. No significant signal is observed in the mass range from the kinematic threshold of the decay to 3800 MeV/c2. An upper limit is set on the ratio of branching fractions R=B(Ξ++cc→D+pK−π+)B(Ξ++cc→Λ+cK−π+π+) with ℛ < 1.7 (2.1) × 10−2 at the 90% (95%) confidence level at the known mass of the Ξ++cc state.