Gold nanomaterials functionalised with gadolinium chelates and their application in multimodal imaging and therapy
File(s)
Accepted version
Author(s)
Perry, Hannah
Botnar, Rene
Wilton-Ely, James
Type
Journal Article
Abstract
Over the last decade, much work has been dedicated to improving the performance of gadolinium-based magnetic resonance imaging (MRI) contrast agents by tethering them to biocompatible gold nanoparticles. The enhancement in performance (measured in terms of ‘relaxivity’) stems from the restriction in motion experienced by the gadolinium chelates on being attached to the gold nanoparticle surface. More recently, the unique properties of gold nanoparticles have been exploited to create very promising tools for multimodal imaging and MRI-guided therapies. This review addresses the progress made in the design of gadolinium-functionalised gold nanoparticles for use in MRI, multimodal imaging and theranostics. It also seeks to connect the chemical properties of these assemblies with potential application in the clinic.
Date Issued
2020-04-14
Date Acceptance
2020-03-23
Citation
Chemical Communications, 2020, 56 (29), pp.4037-4046
ISSN
1359-7345
Publisher
Royal Society of Chemistry (RSC)
Start Page
4037
End Page
4046
Journal / Book Title
Chemical Communications
Volume
56
Issue
29
Copyright Statement
© The Royal Society of Chemistry 2020
Sponsor
The Leverhulme Trust
Imperial College/Wellcome Trust Facility Network of Excellence scheme
Identifier
https://pubs.rsc.org/en/Content/ArticleLanding/2020/CC/D0CC00196A#!divAbstract
Grant Number
RPG-2012-634
P52862
Subjects
Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
MRI CONTRAST AGENTS
PHOTOTHERMAL THERAPY
SURFACE FUNCTIONALIZATION
GRAPHENE OXIDE
IN-VITRO
NANOPARTICLES
CANCER
NANORODS
RELAXIVITY
NANOCLUSTERS
Organic Chemistry
03 Chemical Sciences
Publication Status
Published
Date Publish Online
2020-03-23