A guide to epigenetics in leukaemia stem cells
Author(s)
Agrawal‐Singh, Shuchi
Bagri, Jaana
Sakakini, Nathalie
Huntly, Brian JP
Type
Journal Article
Abstract
Leukaemia stem cells (LSCs) are the critical seed for the growth of haematological malignancies, driving the clonal expansion that enables disease initiation, relapse and often resistance. Specifically, they display inherent phenotypic and epigenetic plasticity resulting in complex heterogenic diseases. In this review, we discuss the key principles of deregulation of epigenetic processes that shape this disease evolution. We consider measures to define and quantify clonal heterogeneity, combining information from recent studies assessing mutational, transcriptional and epigenetic landscapes at single cell resolution in myeloid neoplasms (MN). We highlight the importance of integrating epigenetic and genetic information to better understand inter- and intra-patient heterogeneity and discuss how this understanding further informs evolution and progression trajectories and subsequent clinical response in MN. Under this topic, we also discuss efforts to identify mechanisms of resistance, by longitudinal analyses of patient samples. Finally, we highlight how we might target these aberrant epigenetic processes for better therapeutic outcomes and to potentially eradicate LSCs.
Date Issued
2023-12-01
Date Acceptance
2023-10-20
Citation
Molecular Oncology, 2023, 17 (12), pp.2493-2506
ISSN
1574-7891
Publisher
Wiley
Start Page
2493
End Page
2506
Journal / Book Title
Molecular Oncology
Volume
17
Issue
12
Copyright Statement
© 2023 The Authors. Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
License URL
Publication Status
Published
Date Publish Online
2023-10-23