The neonate versus adult mammalian immune system in cardiac repair and regeneration
File(s)
Accepted version
Author(s)
Sattler, S
Rosenthal, N
Type
Journal Article
Abstract
The immune system is a crucial player in tissue homeostasis and wound
healing. A sophisticated cascade of events triggered upon injury ensures
protection from infection and initiates and orchestrates healing. While the
neonatal mammal can readily regenerate damaged tissues, adult regenerative
capacity is limited to specific tissue types, and in organs such as the heart,
adult wound healing results in fibrotic repair and loss of function. Growing
evidence suggests that the immune system greatly influences the balance
between regeneration and fibrotic repair. The neonate mammalian immune
system has impaired pro-inflammatory function, is prone to T-helper type 2
responses and has an immature adaptive immune system skewed towards
regulatory T cells. While these characteristics make infants susceptible to
infection and prone to allergies, it may also provide an immunological
environment permissive of regeneration.
In this review we will give a comprehensive overview of the immune cells
involved in healing and regeneration of the heart and explore differences
between the adult and neonate immune system that may explain differences
in regenerative ability.
healing. A sophisticated cascade of events triggered upon injury ensures
protection from infection and initiates and orchestrates healing. While the
neonatal mammal can readily regenerate damaged tissues, adult regenerative
capacity is limited to specific tissue types, and in organs such as the heart,
adult wound healing results in fibrotic repair and loss of function. Growing
evidence suggests that the immune system greatly influences the balance
between regeneration and fibrotic repair. The neonate mammalian immune
system has impaired pro-inflammatory function, is prone to T-helper type 2
responses and has an immature adaptive immune system skewed towards
regulatory T cells. While these characteristics make infants susceptible to
infection and prone to allergies, it may also provide an immunological
environment permissive of regeneration.
In this review we will give a comprehensive overview of the immune cells
involved in healing and regeneration of the heart and explore differences
between the adult and neonate immune system that may explain differences
in regenerative ability.
Date Issued
2016-01-20
Date Acceptance
2016-01-18
Citation
BBA - Molecular Cell Research, 2016, 1863 (7, Part B), pp.1813-1821
ISSN
0167-4889
Publisher
Elsevier
Start Page
1813
End Page
1821
Journal / Book Title
BBA - Molecular Cell Research
Volume
1863
Issue
7, Part B
Copyright Statement
© 2016, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor
Fondation Leducq
Grant Number
13 CVD 01
Subjects
Adult
Fibrosis
Heart
Immune system
Myocardial infarct
Neonate
Regeneration
Biochemistry & Molecular Biology
0601 Biochemistry And Cell Biology
1108 Medical Microbiology
06 Biological Sciences
02 Physical Sciences
Publication Status
Published