Genetic control strategies for population suppression in the Anopheles gambiae complex: a review of current technologies
File(s)
Published version
Author(s)
Simoni, Alekos
Tolosana, Ignacio
Bernardini, Federica
Type
Journal Article
Abstract
Malaria continues to pose a critical public health threat, with mosquitoes from the Anopheles gambiae complex acting as the main vectors of the disease in sub-Saharan Africa, where approximately 95% of malaria-related deaths occur. Despite significant advancements in vector control, such as insecticide-treated bed nets and indoor spraying, the effectiveness of these interventions is increasingly compromised by various challenges, including rising levels of insecticide and pathogen resistance, mosquito behavioural adaptations, and persistent funding gaps. In this context, genetic vector control strategies have shown considerable promise, primarily based on findings from controlled laboratory studies. This review explores the development of these genetic approaches within the Anopheles gambiae complex and outlines future directions for their advancement and potential integration into malaria control efforts.
Date Issued
2025-12-01
Date Acceptance
2025-08-01
Citation
Current Opinion in Insect Science, 2025, 72
ISSN
2214-5745
Publisher
Elsevier
Journal / Book Title
Current Opinion in Insect Science
Volume
72
Copyright Statement
© 2025 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/40850662
PII: S2214-5745(25)00100-2
Subjects
ALBIMANUS
Biology
CHEMOSTERILIZED MALES
DRIVE
Ecology
EL-SALVADOR
Entomology
Environmental Sciences & Ecology
Life Sciences & Biomedicine
Life Sciences & Biomedicine - Other Topics
RELEASE
Science & Technology
Publication Status
Published
Coverage Spatial
Netherlands
Article Number
101430
Date Publish Online
2025-08-22