Plasma exchange in anti-glomerular basement membrane disease
File(s)
Accepted version
Author(s)
Prendecki, Maria
Pusey, Charles
Type
Journal Article
Abstract
Anti-glomerular basement membrane (GBM) disease is a rare autoimmune vasculitis characterised by antibodies directed against the non collagenous (NC1) domain of the α3 chain of type 4 collagen (α3(IV)NC1). Clinical features are typically of a rapidly progressive glomerulonephritis (RPGN) with or without pulmonary haemorrhage. Treatment aims to rapidly remove circulating autoantibodies with plasma exchange and prevent further antibody production and suppress inflammation using immunosuppression and corticosteroids. Retrospective studies have shown that this combination of treatment results in good renal outcomes compared to historical controls. Disease relapse is uncommon and, unless patients have a co-existing antineutrophil cytoplasm antibody, maintenance treatment is not required.
Date Issued
2019-11-01
Date Acceptance
2019-03-11
Citation
La Presse medicale, 2019, 48 (11, Part 2), pp.328-337
ISSN
0032-7867
Publisher
Elsevier Masson
Start Page
328
End Page
337
Journal / Book Title
La Presse medicale
Volume
48
Issue
11, Part 2
Copyright Statement
© 2019 Elsevier Masson SAS. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/31703956
PII: S0755-4982(19)30470-1
Subjects
General & Internal Medicine
Publication Status
Published
Coverage Spatial
France
Date Publish Online
2019-11-05