Metabolic Syndrome, Independent of Its Components, Is a Risk Factor for Stroke and Death But Not for Coronary Heart Disease Among Hypertensive Patients in the ASCOT-BPLA
Author(s)
Gupta, AK
Dahlof, B
Sever, PS
Poulter, NR
Type
Journal Article
Abstract
OBJECTIVE — To evaluate whether in hypertensive patients the risk of cardiovascular disease
is greater in association with the metabolic syndrome (MetS) or the sum of its individual
components.
RESEARCH DESIGN AND METHODS — Cox regression analysis models were developed
to assess the influence of age, sex, ethnicity, and the individual components of MetS on risk
associated with the MetS (using several definitions) of coronary outcomes, stroke, and all-cause
mortality.
RESULTS — MetS was significantly associated with coronary outcomes, stroke, and all-cause
mortality after adjusting for age, sex, and ethnicity. However, when the model was further
adjusted for the individual components, MetS was associated with significantly increased risk of
stroke (hazard ratio 1.34 [95% CI 1.07–1.68]) and all-cause mortality (1.35 [1.16–1.58]) but
not coronary outcomes (fatal coronary heart disease plus nonfatal myocardial infarction 1.16
[0.95–1.43] and total coronary events 1.06 [0.91–1.24]).
CONCLUSIONS — MetS, independent of its individual components, is associated with
increased risk of stroke and all-cause mortality but not coronary outcomes.
is greater in association with the metabolic syndrome (MetS) or the sum of its individual
components.
RESEARCH DESIGN AND METHODS — Cox regression analysis models were developed
to assess the influence of age, sex, ethnicity, and the individual components of MetS on risk
associated with the MetS (using several definitions) of coronary outcomes, stroke, and all-cause
mortality.
RESULTS — MetS was significantly associated with coronary outcomes, stroke, and all-cause
mortality after adjusting for age, sex, and ethnicity. However, when the model was further
adjusted for the individual components, MetS was associated with significantly increased risk of
stroke (hazard ratio 1.34 [95% CI 1.07–1.68]) and all-cause mortality (1.35 [1.16–1.58]) but
not coronary outcomes (fatal coronary heart disease plus nonfatal myocardial infarction 1.16
[0.95–1.43] and total coronary events 1.06 [0.91–1.24]).
CONCLUSIONS — MetS, independent of its individual components, is associated with
increased risk of stroke and all-cause mortality but not coronary outcomes.
Date Issued
2010-07-01
Date Acceptance
2010-03-27
Citation
Diabetes Care, 2010, 33 (7), pp.1647-1651
ISSN
1935-5548
Publisher
American Diabetes Association
Start Page
1647
End Page
1651
Journal / Book Title
Diabetes Care
Volume
33
Issue
7
Copyright Statement
© 2010 by the American Diabetes Association. Readers may use this article as long as the work is properly
cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.
org/licenses/by-nc-nd/3.0/ for details.
cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.
org/licenses/by-nc-nd/3.0/ for details.
Sponsor
Imperial College Healthcare NHS Trust- BRC Funding
National Institute for Health Research
Grant Number
RDC02 79560
n/a
Subjects
Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
ENDOCRINOLOGY & METABOLISM
CARDIOVASCULAR EVENTS
INCIDENT STROKE
ATHEROSCLEROSIS
DEFINITIONS
PREVENTION
PREDICTION
MORTALITY
HEALTH
Publication Status
Published