Rules for body fat interventions based on an operating point mechanism
File(s)
Published version
Author(s)
Bar, Alon
Karin, Omer
Mayo, Avi
Ben-Zvi, Danny
Alon, Uri
Type
Journal Article
Abstract
Interventions to reduce fat are important for human health. However, they can have opposing effects such as exercise that decreases fat but increases food intake, or coherent effects such as leptin resistance which raises both. Furthermore, some interventions show an overshoot in food intake, such as recovery from a diet, whereas others do not. To explain these properties we present a graphical framework called the operating point model, based on leptin control of feeding behavior. Steady-state fat and food intake is given by the intersection of two experimental curves – steady-state fat at a given food intake and ad libitum food intake at a given fat level. Depending on which curve an intervention shifts, it has opposing or coherent effects with or without overshoot, in excellent agreement with rodent data. The model also explains the quadratic relation between leptin and fat in humans. These concepts may guide the understanding of fat regulation disorders.
Date Issued
2023-02-17
Date Acceptance
2023-01-20
Citation
iScience, 2023, 26 (2)
ISSN
2589-0042
Publisher
Elsevier
Journal / Book Title
iScience
Volume
26
Issue
2
Copyright Statement
© 2023 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
License URL
Identifier
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000990645500001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
Subjects
BASAL METABOLIC-RATE
CIRCULATING LEPTIN
ENERGY-INTAKE
FEEDBACK SIGNALS
HIGH-PROTEIN DIET
LEPTIN CONCENTRATIONS
MATHEMATICAL-MODEL
Multidisciplinary Sciences
PLASMA LEPTIN
REDUCES FOOD-INTAKE
Science & Technology
Science & Technology - Other Topics
THYROID-HORMONE
Publication Status
Published
Coverage Spatial
United States
Article Number
106047
Date Publish Online
2023-01-25