A prenylated dsRNA sensor protects against severe COVID-19

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science.abj3624.pdf (2.66 MB)

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OA Location

https://www.science.org/doi/10.1126/science.abj3624

Author(s)

Wickenhagen, Arthur

Sugrue, Elena

Lytras, Spyros

Kuchi, Srikeerthana

Noerenberg, Marko

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Type

Journal Article

Date Issued

2021-10-29

Date Acceptance

2021-09-23

Citation

Science, 2021, 374 (6567), pp.1-18

URI

http://hdl.handle.net/10044/1/95147

DOI

https://www.dx.doi.org/10.1126/science.abj3624

ISSN

0036-8075

Publisher

Amer Assoc Advancement Science

Start Page

1

End Page

18

Journal / Book Title

Science

Volume

374

Issue

6567

Copyright Statement

© 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).
This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0/

License URL

Attribution 4.0 International

Sponsor

National Institute for Health Research

UK Research and Innovation

UKRI MRC COVID-19 Rapid Response Call

Identifier

http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000714943400033&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202

Grant Number

RP-2016-07-012

9815274 MC_PC_19025

MC_PC19025

Subjects

Science & Technology

Multidisciplinary Sciences

Science & Technology - Other Topics

SINGLE-NUCLEOTIDE POLYMORPHISM

SPLICE-SITE POLYMORPHISM

VIRUS NS1 PROTEIN

RNASE-L

CORONAVIRUS REPLICATION

SARS-CORONAVIRUS

ENZYME-ACTIVITY

ACCEPTOR SITE

I INTERFERON

L PATHWAY

Publication Status

Published

Article Number

ARTN 579

Date Publish Online

2021-09-28