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Reducing onchocerciasis-associated morbidity in onchocerciasis-endemic foci with high ongoing transmission: a focus on the children
File(s)
Author(s)
Colebunders, Robert
Kaiser, Christoph
Basanez, Maria-Gloria
Olliaro, Piero
Lakwo, Tom
Type
Journal Article
Abstract
Efforts are being directed toward the elimination of onchocerciasis transmission in endemic areas with community-directed treatment with ivermectin (CDTI) in Africa, which greatly reduces onchocerciasis-associated disease. However, onchocerciasis remains a major public health problem in areas of South Sudan, the Democratic Republic of the Congo, Cameroon, and the Central African Republic. Strengthening onchocerciasis elimination efforts in areas with a high prevalence of disease burden is crucial to decrease transmission, morbidity, and mortality. We argue that clinical trials are needed to investigate the safety and efficacy of ivermectin treatment of Onchocerca volvulus-infected pregnant women and children younger than 5 years. Crucially, 6-monthly administration of ivermectin in school-age children at risk of onchocerciasis-associated epilepsy could be achieved by supplementing annual CDTI with an extra round of ivermectin treatment during Child Health Days in schools and/or other distribution sites every year. These strategies would help achieve the elimination of onchocerciasis and its associated disease burden.
Date Issued
2022-03-01
Date Acceptance
2022-01-18
Citation
International Journal of Infectious Diseases, 2022, 116, pp.302-305
URI
URL
DOI
ISSN
1201-9712
Publisher
Elsevier
Start Page
302
End Page
305
Journal / Book Title
International Journal of Infectious Diseases
Volume
116
Copyright Statement
© 2022 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/35074518
PII: S1201-9712(22)00047-9
Subjects
elimination
epilepsy
EPILEPSY
Infectious Diseases
ivermectin
IVERMECTIN
Life Sciences & Biomedicine
nodding syndrome
Onchocerciasis
school-age children
Science & Technology
VOLVULUS
Publication Status
Published
Coverage Spatial
Canada
Date Publish Online
2022-01-21