Clinical 18F-FDG and amyloid brain positron emission tomography/CT in the investigation of cognitive impairment: where are we now?
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
The number of people living with dementia is increasing, but as yet there remains no cure or disease-modifying treatment. This review aims to help readers understand the role of 18F-FDG PET/CT imaging in the investigation of cognitive impairment and how the advent of amyloid PET/CT imaging may hold the key to radically changing management of the most common form of dementia - Alzheimer's disease. The indications for 18F-FDG PET/CT and amyloid PET/CT imaging in cognitive impairment are outlined. Additionally, the mechanisms of action, technique, patient preparation and acquisition parameters for both are detailed. We conclude by providing a framework for interpreting 18F-FDG PET/CT and amyloid PET/CT imaging in the more common conditions that lead to cognitive impairment conditions with tips on avoiding pitfalls in interpretation.
Date Issued
2019-01-01
Date Acceptance
2019-04-03
Citation
British Journal of Radiology, 92 (1101)
ISSN
0007-1285
Publisher
British Institute of Radiology
Journal / Book Title
British Journal of Radiology
Volume
92
Issue
1101
Copyright Statement
© 2019 British Institute of Radiology
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/30982329
Subjects
Science & Technology
Life Sciences & Biomedicine
Radiology, Nuclear Medicine & Medical Imaging
ALZHEIMERS-DISEASE
NATIONAL INSTITUTE
PET
DIAGNOSIS
DEMENTIA
FDG
ANGIOPATHY
Amyloidogenic Proteins
Brain
Cognitive Dysfunction
Fluorodeoxyglucose F18
Humans
Neuroimaging
Positron Emission Tomography Computed Tomography
Radiopharmaceuticals
Brain
Humans
Fluorodeoxyglucose F18
Radiopharmaceuticals
Amyloidogenic Proteins
Neuroimaging
Cognitive Dysfunction
Positron Emission Tomography Computed Tomography
1103 Clinical Sciences
Nuclear Medicine & Medical Imaging
Publication Status
Published online
Coverage Spatial
England
Article Number
20181027
Date Publish Online
2019-05-14