Zero- to ultralow-field nuclear magnetic resonance enhanced with dissolution dynamic nuclear polarization
File(s)
Accepted version
OA Location
Author(s)
Type
Journal Article
Abstract
Zero- to ultralow-field nuclear magnetic resonance is a modality of magnetic resonance experiment which does not require strong superconducting magnets. Contrary to conventional high-field nuclear magnetic resonance, it has the advantage of allowing high-resolution detection of nuclear magnetism through metal as well as within heterogeneous media. To achieve high sensitivity, it is common to couple zero-field nuclear magnetic resonance with hyperpolarization techniques. To date, the most common technique is parahydrogen-induced polarization, which is only compatible with a small number of compounds. In this article, we establish dissolution dynamic nuclear polarization as a versatile method to enhance signals in zero-field nuclear magnetic resonance experiments on sample mixtures of [13C]sodium formate, [1-13C]glycine, and [2-13C]sodium acetate, and our technique is immediately extendable to a broad range of molecules with >1 s relaxation times. We find signal enhancements of up to 11,000 compared with thermal prepolarization in a 2 T permanent magnet. To increase the signal in future experiments, we investigate the relaxation effects of the TEMPOL radicals used for the hyperpolarization process at zero- and ultralow-fields.
Date Issued
2023-01-17
Date Acceptance
2022-11-22
Citation
Analytical Chemistry, 2023, 95 (2), pp.720-729
ISSN
0003-2700
Publisher
American Chemical Society
Start Page
720
End Page
729
Journal / Book Title
Analytical Chemistry
Volume
95
Issue
2
Copyright Statement
Copyright © 2022 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Analytical Chemistry, after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.analchem.2c02649
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/36563171
Subjects
Chemistry
Chemistry, Analytical
INJECTION
LIQUIDS
Physical Sciences
RELAXATION
Science & Technology
SPECTROSCOPY
TIMES
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2022-12-23