Accelerated long-term forgetting can become apparent within 3-8 hours of wakefulness in patients with transient epileptic amnesia
Author(s)
Hoefeijzers, S
Dewar, M
Della Sala, S
Butler, C
Zeman, A
Type
Journal Article
Abstract
Objective: Accelerated long-term forgetting (ALF) is typically defined as a memory disorder in which information that is learned and retained normally over standard intervals (∼30 min) is forgotten at an abnormally rapid rate thereafter. ALF has been reported, in particular, among patients with transient epileptic amnesia (TEA). Previous work in TEA has revealed ALF 24 hr - 1 week after initial memory acquisition. It is unclear, however, if ALF observed 24 hr after acquisition reflects (a) an impairment of sleep consolidation processes taking place during the first night’s sleep, or (b) an impairment of daytime consolidation processes taking place during the day of acquisition. Here we focus on the daytime-forgetting hypothesis of ALF in TEA by tracking in detail the time course of ALF over the day of acquisition, as well as over 24 hr and 1 week. Method: Eleven TEA patients who showed ALF at 1 week and 16 matched controls learned 4 categorical word lists on the morning of the day of acquisition. We subsequently probed word-list retention 30 min, 3 hr, and 8 hr postacquisition (i.e., over the day of acquisition), as well as 24-hr and 1-week post acquisition. Results: ALF became apparent in the TEA group over the course of the day of acquisition 3–8 hr after learning. No further forgetting was observed over the first night in either group. Conclusions: The results of this study show that ALF in TEA can result from a deficit in memory consolidation occurring within hours of learning without a requirement for intervening sleep.
Date Issued
2015-01-01
Online Publication Date
2021-08-20T14:18:17Z
Date Acceptance
2014-05-09
ISSN
0894-4105
Publisher
American Psychological Association
Start Page
117
End Page
125
Journal / Book Title
Neuropsychology
Volume
29
Issue
1
Copyright Statement
© 2014 The Author(s). This article has been published under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the author(s). Author(s) grant(s) the American Psychological Association the exclusive right to publish the article and identify itself as the original publisher.
License URI
Identifier
https://doi.apa.org/fulltext/2014-31788-001.html
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000347232800014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Social Sciences
Science & Technology
Life Sciences & Biomedicine
Psychology, Clinical
Neurosciences
Psychology
Neurosciences & Neurology
accelerated long-term forgetting
transient epileptic amnesia
memory
consolidation
epilepsy
TEMPORAL-LOBE EPILEPSY
MEMORY CONSOLIDATION
RECALL
INTERFERENCE
ASSOCIATION
IMPAIRMENT
INSIGHTS
SLEEP
AGE
Adult
Amnesia
Epilepsy
Female
Humans
Learning
Male
Memory
Memory Disorders
Mental Recall
Neuropsychological Tests
Sleep
Time Factors
Wakefulness
Humans
Epilepsy
Memory Disorders
Amnesia
Learning
Memory
Mental Recall
Wakefulness
Sleep
Neuropsychological Tests
Time Factors
Adult
Female
Male
Social Sciences
Science & Technology
Life Sciences & Biomedicine
Psychology, Clinical
Neurosciences
Psychology
Neurosciences & Neurology
accelerated long-term forgetting
transient epileptic amnesia
memory
consolidation
epilepsy
TEMPORAL-LOBE EPILEPSY
MEMORY CONSOLIDATION
RECALL
INTERFERENCE
ASSOCIATION
IMPAIRMENT
INSIGHTS
SLEEP
AGE
Experimental Psychology
1109 Neurosciences
1701 Psychology
1702 Cognitive Sciences
Publication Status
Published
Date Publish Online
2014-08-04