Nutrient-wide association study of 92 foods and nutrients and breast cancer risk
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Background: Several dietary factors have been reported to be associated with risk of breast cancer, but to date unequivocal evidence only exists for alcohol consumption. We sought to systematically assess the association between intake of 92 foods and nutrients and breast cancer risk using a nutrient-wide association study. Methods: Using data from 272,098 women participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, we assessed dietary intake of 92 foods and nutrients estimated by dietary questionnaires. Cox regression was used to quantify the association between each food/nutrient and risk of breast cancer. A false discovery rate (FDR) of 0.05 was used to select the set of foods and nutrients to be replicated in the independent Netherlands Cohort Study (NLCS). Results: Six foods and nutrients were identified as associated with risk of breast cancer in the EPIC study (10,979 cases). Higher intake of alcohol overall was associated with a higher risk of breast cancer (hazard ratio (HR) for a 1 SD increment in intake = 1.05, 95% CI 1.03–1.07), as was beer/cider intake and wine intake (HRs per 1 SD increment = 1.05, 95% CI 1.03–1.06 and 1.04, 95% CI 1.02–1.06, respectively), whereas higher intakes of fibre, apple/pear, and carbohydrates were associated with a lower risk of breast cancer (HRs per 1 SD increment = 0.96, 95% CI 0.94–0.98; 0.96, 95% CI 0.94–0.99; and 0.96, 95% CI 0.95–0.98, respectively). When evaluated in the NLCS (2368 cases), estimates for each of these foods and nutrients were similar in magnitude and direction, with the exception of beer/cider intake, which was not associated with risk in the NLCS Conclusions: Our findings confirm a positive association of alcohol consumption and
suggest an inverse association of dietary fibre and possibly fruit intake with breast cancer risk.
suggest an inverse association of dietary fibre and possibly fruit intake with breast cancer risk.
Date Issued
2020-01-13
Date Acceptance
2019-12-30
Citation
Breast Cancer Research, 2020, 22 (5)
ISSN
1465-542X
Publisher
BMC
Journal / Book Title
Breast Cancer Research
Volume
22
Issue
5
Copyright Statement
© The Author(s). 2020 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver
(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver
(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Sponsor
Cancer Research UK
Cancer Research UK
Identifier
https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-019-1244-7
Grant Number
C57955/A24390
24390
Subjects
Science & Technology
Life Sciences & Biomedicine
Oncology
Breast cancer
Diet
Foods
Nutrients
Alcohol
Fibre
DIETARY FIBER INTAKE
SERUM ESTROGEN CONCENTRATIONS
SCALE PROSPECTIVE COHORT
POSTMENOPAUSAL WOMEN
POOLED ANALYSIS
ALCOHOL
NUTRITION
PREMENOPAUSAL
QUESTIONNAIRE
METAANALYSIS
Alcohol
Breast cancer
Diet
Fibre
Foods
Nutrients
Oncology & Carcinogenesis
1112 Oncology and Carcinogenesis
Publication Status
Published
Date Publish Online
2020-01-13