Impact of CT-apelin and NT-proBNP on identifying non-responders to cardiac resynchronization therapy
Author(s)
Type
Journal Article
Abstract
CONTEXT: Assessment of response to cardiac resynchronization therapy (CRT) is essential. OBJECTIVE: To assess the predictive value of CT-apelin together with NT-proBNP in patients undergoing CRT. METHODS: Serum CT-apelin and NT-proBNP were measured by ELISA before, and 6-month after CRT. Primary endpoint was non-response (<4% increase in LVEF) after 6-month. RESULTS: From 81 patients, 15 proved to be non-responders. Six-month CT-apelin was superior compared to NT-proBNP in identifying non-responders by multivariate ROC (CT-apelin:p = 0.01, NT-proBNP:p = 0.13) and by logistic regression (CT-apelin:p = 0.01, NT-proBNP:p = 0.41) analyzes. CONCLUSION: Six-month CT-apelin might be valuable novel biomarker in identifying non-responders to CRT that was superior to NT-proBNP.
Date Issued
2016-08-12
Date Acceptance
2016-07-23
Citation
Biomarkers, 2016, 22 (3-4), pp.279-286
ISSN
1366-5804
Publisher
Taylor and Francis
Start Page
279
End Page
286
Journal / Book Title
Biomarkers
Volume
22
Issue
3-4
Copyright Statement
© 2016 Taylor & Francis. This is an Author's Accepted Manuscript of an article published in Biomarkers, available online at: http://dx.doi.org/10.1080/1354750X.2016.1217931.
Subjects
Science & Technology
Life Sciences & Biomedicine
Biotechnology & Applied Microbiology
Toxicology
Cardiovascular disease
renal disease
apelin
NT-proBNP
CRT responder
BRAIN NATRIURETIC PEPTIDE
DEFIBRILLATOR IMPLANTATION TRIAL
CHRONIC HEART-FAILURE
ENDOGENOUS INOTROPE APELIN
ORPHAN RECEPTOR APJ
MADIT-CRT
VAL-HEFT
IN-VIVO
CONTRACTILITY
DYSSYNCHRONY
Aged
Biomarkers
Cardiac Resynchronization Therapy
Female
Humans
Intercellular Signaling Peptides and Proteins
Male
Middle Aged
Natriuretic Peptide, Brain
Peptide Fragments
Predictive Value of Tests
Regression Analysis
Treatment Outcome
1002 Environmental Biotechnology
Publication Status
Published