Cortisol, dehydroepiandrosterone sulphate, their ratio and hypertension: evidence of associations in male veterans from the Vietnam Experience Study
Author(s)
Carroll, D
Phillips, AC
Lord, JM
Arlt, W
Batty, GD
Type
Journal Article
Abstract
Although clinical observations implicate cortisol in hypertension, the epidemiological evidence is less compelling. Little is known about the relationship between dehydroepiandrosterone sulphate (DHEAS) and hypertension, and nothing about the association with the cortisol:DHEAS ratio. The present analyses of data obtained from Vietnam-era US veterans examined the associations between cortisol, DHEAS, their ratio and hypertension. Participants were 4180 male veterans. From military files, telephone interviews and a medical examination, sociodemographic and health data were collected. At medical examination, a fasted morning blood sample was collected to assay serum cortisol and DHEAS, blood pressure measured and body mass index (BMI) determined. Hypertension was defined by having one of the following: a reported physician diagnosis, taking antihypertensive medication, an average systolic blood pressure ⩾140 mm Hg and an average diastolic blood pressure ⩾90 mm Hg. Cortisol and the cortisol:DHEAS ratio were positively associated with hypertension (P<0.001), whereas DHEAS was negatively associated; the latter relationship was attenuated to non-significance (P=0.06) in models that adjusted for age, sociodemographics, place of service, health behaviours and BMI. The present analyses provide confirmation of a positive association between cortisol and the cortisol:DHEAS ratio and population hypertension.
Date Issued
2011-07-01
Date Acceptance
2010-12-25
Citation
Journal of Human Hypertension, 2011, 25 (7), pp.418-424
ISSN
0950-9240
Publisher
Springer Nature [academic journals on nature.com]
Start Page
418
End Page
424
Journal / Book Title
Journal of Human Hypertension
Volume
25
Issue
7
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/21307886
PII: jhh20116
Subjects
BLOOD-PRESSURE
CARDIOVASCULAR RISK-FACTORS
Cardiovascular System & Cardiology
cortisol
cortisol:dehydroepiandrosterone sulphate ratio
dehydroepiandrosterone sulphate
GENERALIZED ANXIETY
INSULIN
LARGE COHORT
Life Sciences & Biomedicine
LOW-BIRTH-WEIGHT
male veterans
METABOLISM
MORTALITY
Peripheral Vascular Disease
PREDICTORS
Science & Technology
SERUM DEHYDROEPIANDROSTERONE
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2011-02-10