Nutrient patterns and risk of breast cancer in Uruguay
File(s)
Author(s)
Type
Journal Article
Abstract
Objectives. To explore the role of nutrient patterns in the etiology of breast cancer (BC) among Uruguayan
women. Methods. A principal component analysis was conducted. The study included 442 newly diagnosed
cases of BC and 442 hospitalized controls. Results. Two dietary patterns derived from factor analysis and were
labeled as high-meat and antioxidants patterns. Whereas the high-meat pattern was directly associated with BC risk (OR for the highest versus the lowest quartile = 3.50, 95 % CI 1.94-6.30, p-value for trend <0.0001), the antioxidants pattern displayed a protective effect (OR=0.44, 95 % CI 0.27-0.74). Its negative association was stronger for postmenopausal than for premenopausal women (OR=0.63, 95% CI 0.51-0.79 vs. OR=0.89, 95% CI 0.50-1.56, respectively). Both strata were heterogeneous (p=0.004). The high-meat pattern was more associated with BC risk among patients with family history of BC compared with participants without it, but results did not differ by histology. In contrast, the antioxidants pattern was more associated with non-ductal cancers (OR=0.50 [95 % CI 0.35-0.69]) than with ductal cancers (OR=0.72, 95 % CI 0.58-0.88, heterogeneity p-value=0.03). Conclusions. Results support an association between the high-meat and antioxidant dietary patterns and BC risk. Furthermore, findings suggest that gene-environmental interactions may be important in BC etiology.
women. Methods. A principal component analysis was conducted. The study included 442 newly diagnosed
cases of BC and 442 hospitalized controls. Results. Two dietary patterns derived from factor analysis and were
labeled as high-meat and antioxidants patterns. Whereas the high-meat pattern was directly associated with BC risk (OR for the highest versus the lowest quartile = 3.50, 95 % CI 1.94-6.30, p-value for trend <0.0001), the antioxidants pattern displayed a protective effect (OR=0.44, 95 % CI 0.27-0.74). Its negative association was stronger for postmenopausal than for premenopausal women (OR=0.63, 95% CI 0.51-0.79 vs. OR=0.89, 95% CI 0.50-1.56, respectively). Both strata were heterogeneous (p=0.004). The high-meat pattern was more associated with BC risk among patients with family history of BC compared with participants without it, but results did not differ by histology. In contrast, the antioxidants pattern was more associated with non-ductal cancers (OR=0.50 [95 % CI 0.35-0.69]) than with ductal cancers (OR=0.72, 95 % CI 0.58-0.88, heterogeneity p-value=0.03). Conclusions. Results support an association between the high-meat and antioxidant dietary patterns and BC risk. Furthermore, findings suggest that gene-environmental interactions may be important in BC etiology.
Date Issued
2010-02-01
Date Acceptance
2010-02-01
Citation
Asian Pacific Journal of Cancer Prevention, 2010, 11 (2), pp.519-524
ISSN
1513-7368
Publisher
West Asia Organization for Cancer Prevention
Start Page
519
End Page
524
Journal / Book Title
Asian Pacific Journal of Cancer Prevention
Volume
11
Issue
2
Copyright Statement
Asia Pacific Journal of Cancer Prevention is under the terms of the Creative Commons Attribution License. This permits anyone to copy, distribute, transmit, and adapt the published work, provided the original work and source are appropriately cited.
Identifier
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000285636600044&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
Subjects
Breast cancer
COHORT
diet
DIETARY PATTERNS
DONENESS
factor analysis
FAT
foods
GASTRIC-CANCER
HEALTH
HETEROCYCLIC AMINE CONTENT
Life Sciences & Biomedicine
MEAT INTAKE
nutrients
Oncology
Science & Technology
VARYING DEGREES
WOMEN
Publication Status
Published
Coverage Spatial
Thailand