Synthesis of triphenylphosphonium vitamin E derivatives as mitochondria-targeted antioxidants
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
A series of mitochondria-targeted antioxidants comprising a lipophilic triphenylphosphonium cation attached to the antioxidant chroman moiety of vitamin E by an alkyl linker have been prepared. The synthesis of a series of mitochondria-targeted vitamin E derivatives with a range of alkyl linkers gave compounds of different hydrophobicities. This work will enable the dependence of antioxidant defence on hydrophobicity to be determined in vivo.
Date Issued
2015-09-05
Date Acceptance
2015-09-04
Citation
Tetrahedron, 2015, 71 (44), pp.8444-8453
ISSN
1464-5416
Publisher
Elsevier
Start Page
8444
End Page
8453
Journal / Book Title
Tetrahedron
Volume
71
Issue
44
Copyright Statement
© 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license
(http://creativecommons.org/licenses/by/4.0/)
(http://creativecommons.org/licenses/by/4.0/)
License URL
Subjects
Science & Technology
Physical Sciences
Chemistry, Organic
Chemistry
Mitochondria
Mitochondria-targeted antioxidant
Lipid peroxidation
Vitamin E
MitoE
ISCHEMIA-REPERFUSION INJURY
OXIDATIVE STRESS
NEURODEGENERATIVE DISEASES
DYSFUNCTION
MITOQ
CANCER
DAMAGE
CELLS
UBIQUINONE
APOPTOSIS
Organic Chemistry
0305 Organic Chemistry
0304 Medicinal And Biomolecular Chemistry
Publication Status
Published