Ophthalmic sensors and drug delivery
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Advances in multifunctional materials and technologies have allowed contact lenses to serve as wearable devices for continuous monitoring of physiological parameters and delivering drugs for ocular diseases. Since the tear fluids comprise a library of biomarkers, direct measurement of different parameters such as concentration of glucose, urea, proteins, nitrite, and chloride ions, intraocular pressure (IOP), corneal temperature, and pH can be carried out non-invasively using contact lens sensors. Microfluidic contact lens sensor based colorimetric sensing and liquid control mechanisms enable the wearers to perform self-examinations at home using smartphones. Furthermore, drug-laden contact lenses have emerged as delivery platforms using a low dosage of drugs with extended residence time and increased ocular bioavailability. This review provides an overview of contact lenses for ocular diagnostics and drug delivery applications. The designs, working principles, and sensing mechanisms of sensors and drug delivery systems are reviewed. The potential applications of contact lenses in point-of-care diagnostics and personalized medicine, along with the significance of integrating multiplexed sensing units together with drug delivery systems, have also been discussed.
Date Issued
2021-06-25
Date Acceptance
2021-05-17
Citation
ACS Sensors, 2021, 6 (6), pp.2046-2076
ISSN
2379-3694
Publisher
American Chemical Society
Start Page
2046
End Page
2076
Journal / Book Title
ACS Sensors
Volume
6
Issue
6
Copyright Statement
© 2021 The Authors. Published by American Chemical Society. This work is published under CC BY-NC.
License URL
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000668374500005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry, Analytical
Nanoscience & Nanotechnology
Chemistry
Science & Technology - Other Topics
ophthalmology
contact lenses
continuous monitoring
physiological parameters
biosensors
biomaterials
photonic crystals
bioavailability
diagnostics
personalized medicine
drug delivery
CONTACT-LENS SENSOR
PHOTONIC CRYSTAL HYDROGEL
IN-VITRO UPTAKE
INTRAOCULAR-PRESSURE
TEAR GLUCOSE
BORONIC ACID
LOTEPREDNOL ETABONATE
AQUEOUS-HUMOR
MICROBIAL KERATITIS
SUSTAINED DELIVERY
Publication Status
Published
Date Publish Online
2021-05-27