Cognitive impairment and health- related quality of life following traumatic brain injury
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
BACKGROUNDCognitive impairment is a common and disabling consequence of traumatic brain injury (TBI) but its impact on health-related quality of life is not well understood.OBJECTIVETo investigate the relationship between cognitive impairment and health-related quality of life (HRQoL) after TBI.METHODSRetrospective, cross-sectional study of a specialist TBI outpatient clinic patient sample. Outcome measures: Addenbrooke's Cognitive Examination Tool - Revised (ACE-R), and SF-36 quality of life, Beck Depression Inventory II (BDI-II), Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) questionnaires.RESULTS240 adults were assessed: n = 172 (71.7% ) moderate-severe, 41 (23.8% ) mild, 27 (11.3% ) symptomatic TBI, 174 (72.5% ) male, median age (range): 44 (22-91) years. TBI patients reported poorer scores on all domains of SF-36 compared to age-matched UK normative data. Cognitively impaired patients reported poorer HRQoL on the physical, social role and emotional role functioning, and mental health domains. Cognitive impairment predicted poorer HRQoL on the social and emotional role functioning domains, independently of depressive symptoms, sleep disturbance, daytime sleepiness and TBI severity. Mediation analysis revealed that the effect of depressive symptoms on the emotional role functioning domain of HRQoL was partially mediated by cognitive dysfunction.CONCLUSIONCognitive impairment is associated with worse health-related quality of life after TBI and partially mediates the effect of depressive symptoms on emotional role functioning.
Date Issued
2019-06-20
Date Acceptance
2019-06-01
Citation
Journal of Alzheimer's Disease, 2019, 44 (3), pp.321-331
ISSN
1387-2877
Publisher
IOS Press
Start Page
321
End Page
331
Journal / Book Title
Journal of Alzheimer's Disease
Volume
44
Issue
3
Copyright Statement
© 2019 IOS Press and the authors. All rights reserved.
Sponsor
Imperial College Healthcare NHS Trust- BRC Funding
Imperial College Healthcare NHS Trust- BRC Funding
National Institute for Health Research
The Academy of Medical Sciences
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/31177238
PII: NRE182618
Grant Number
RDA03_79560
RDC04
NIHR-RP-011-048
N/A
Subjects
SF-36
TBI
cognition
depression
sleep disturbance
Publication Status
Published
Coverage Spatial
Netherlands
Date Publish Online
2019-06-20