Evidence update for the treatment of anaphylaxis
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Supporting information
Published version
Author(s)
Type
Journal Article
Abstract
The Resuscitation Council UK has updated its Guideline for healthcare providers on the Emergency treatment of anaphylaxis. As part of this process, an evidence review was undertaken by the Guideline Working Group, using an internationally-accepted approach for adoption, adaptation, and de novo guideline development based on the Grading of Recommendations Assessment, Development and Evaluation (GRADE) evidence to decision (EtD) framework, referred to as GRADE-ADOLOPMENT. A number of significant changes have been made, which will be reflected in the updated Guideline. These include: emphasis on repeating intramuscular adrenaline doses after 5 min if symptoms of anaphylaxis do not resolve; corticosteroids (e.g. hydrocortisone) no longer being routinely recommended for the emergency treatment of anaphylaxis; interventions for reactions which are refractory to initial treatment with adrenaline; a recommendation against the use of antihistamines for the acute management of anaphylaxis; and guidance relating to the duration of observation following anaphylaxis, and timing of discharge.
Date Issued
2021-06-01
Online Publication Date
2021-06-14T11:42:21Z
Date Acceptance
2021-04-12
ISSN
0300-9572
Publisher
Elsevier
Start Page
86
End Page
96
Journal / Book Title
Resuscitation
Volume
163
Copyright Statement
© 2021 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
License URI
Sponsor
Medical Research Council (MRC)
National Institute for Health Research
Food Standards Agency
Grant Number
MR/K010468/1
RDD02
FS101222
Subjects
Adrenaline
Anaphylaxis
Antihistamine
Corticosteroids
Resuscitation
Emergency & Critical Care Medicine
1103 Clinical Sciences
1110 Nursing
1117 Public Health and Health Services
Publication Status
Published
Date Publish Online
2021-04-23