Variant-specific symptoms of COVID-19 in a study of 1,542,510 adults in England
File(s)s41467-022-34244-2.pdf (2.1 MB)
Published version
Author(s)
Type
Journal Article
Abstract
Infection with SARS-CoV-2 virus is associated with a wide range of symptoms. The REal-time Assessment of Community Transmission -1 (REACT-1) study monitored the spread and clinical manifestation of SARS-CoV-2 among random samples of the population in England from 1 May 2020 to 31 March 2022. We show changing symptom profiles associated with the different variants over that period, with lower reporting of loss of sense of smell or taste for Omicron compared to previous variants, and higher reporting of cold-like and influenza-like symptoms, controlling for vaccination status. Contrary to the perception that recent variants have become successively milder, Omicron BA.2 was associated with reporting more symptoms, with greater disruption to daily activities, than BA.1. With restrictions lifted and routine testing limited in many countries, monitoring the changing symptom profiles associated with SARS-CoV-2 infection and effects on daily activities will become increasingly important.
Date Issued
2022-11-11
Date Acceptance
2022-10-19
Citation
Nature Communications, 2022, 13, pp.1-10
ISSN
2041-1723
Publisher
Nature Research
Start Page
1
End Page
10
Journal / Book Title
Nature Communications
Volume
13
Copyright Statement
© The Author(s) 2022
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Sponsor
Cancer Research UK
Commission of the European Communities
Commission of the European Communities
National Institute for Health Research
Imperial College Healthcare NHS Trust- BRC Funding
Wellcome Trust
National Institute for Health Research
Department of Health
Abdul Latif Jameel Foundation
Imperial College Healthcare NHS Trust: Research Capability Funding (RCF)
Department of Health
Medical Research Council (MRC)
Medical Research Council (MRC)
Identifier
https://www.nature.com/articles/s41467-022-34244-2
Grant Number
‘Mechanomics’ PRC project grant 22184
874627
874739
COV-LT-0040
RDF01
205456/A/16/Z
NF-SI-0617-10116
n/a
RDF04
n/a
MR/R015600/1
MR/S019669/1
Subjects
Adult
Humans
COVID-19
SARS-CoV-2
England
Humans
Adult
England
COVID-19
SARS-CoV-2
Publication Status
Published
Article Number
6856
Date Publish Online
2022-11-11