Fetal size and growth velocity in chronic hypertension
Author(s)
Type
Journal Article
Abstract
Objective
To investigate longitudinal fetal growth and growth velocity for commonly measured biometric parameters in women with chronic hypertension.
Methods
Two centre retrospective European study of women with chronic hypertension ascertained at pregnancy booking. Ultrasound measurements of head circumference (HC), abdominal circumference (AC) and femur length (FL) were used to derive longitudinal fetal growth charts derived using functional linear discriminant analysis (FLDA). These were compared to existing cross sectional and longitudinal charts, as was birthweight.
Results
282 women with a median of 3 third trimester ultrasound examinations were included. Gestation at delivery was 37.5 weeks (SD 2.68), birthweight 3049 g (SD 785). Birthweight <10th percentile found in 15.6% deliveries, >90th percentile 20.2%. Fetal size curves derived from women with chronic hypertension were no different to cross sectional and longitudinal charts for a normal population. Compared to a standard longitudinal biometry chart, growth velocity (mm/day) in chronic hypertension was higher for AC and FL at 30–32 weeks (AC 1.447 vs 1.357 p < 0.05; FL 0.296 vs 0.269 p < 0.01) and 34–36 weeks (AC 1.325 vs 1.140 p < 0.01; FL 0.248 vs 0.198 p < 0.01).
Conclusions
In women with chronic hypertension there is an excess of both SGA and LGA babies compared to population standards. Growth velocity of the AC and FL was greater after 30 weeks compared to a normal population.
To investigate longitudinal fetal growth and growth velocity for commonly measured biometric parameters in women with chronic hypertension.
Methods
Two centre retrospective European study of women with chronic hypertension ascertained at pregnancy booking. Ultrasound measurements of head circumference (HC), abdominal circumference (AC) and femur length (FL) were used to derive longitudinal fetal growth charts derived using functional linear discriminant analysis (FLDA). These were compared to existing cross sectional and longitudinal charts, as was birthweight.
Results
282 women with a median of 3 third trimester ultrasound examinations were included. Gestation at delivery was 37.5 weeks (SD 2.68), birthweight 3049 g (SD 785). Birthweight <10th percentile found in 15.6% deliveries, >90th percentile 20.2%. Fetal size curves derived from women with chronic hypertension were no different to cross sectional and longitudinal charts for a normal population. Compared to a standard longitudinal biometry chart, growth velocity (mm/day) in chronic hypertension was higher for AC and FL at 30–32 weeks (AC 1.447 vs 1.357 p < 0.05; FL 0.296 vs 0.269 p < 0.01) and 34–36 weeks (AC 1.325 vs 1.140 p < 0.01; FL 0.248 vs 0.198 p < 0.01).
Conclusions
In women with chronic hypertension there is an excess of both SGA and LGA babies compared to population standards. Growth velocity of the AC and FL was greater after 30 weeks compared to a normal population.
Date Issued
2017-10-01
Date Acceptance
2017-06-20
Citation
Pregnancy Hypertension, 2017, 10, pp.101-106
ISSN
2210-7789
Publisher
Elsevier
Start Page
101
End Page
106
Journal / Book Title
Pregnancy Hypertension
Volume
10
Copyright Statement
© 2017 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000415611600019&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Obstetrics & Gynecology
Peripheral Vascular Disease
Cardiovascular System & Cardiology
Abdominal circumference
Biparietal diameter
Femur length
FLDA
Head circumference
LINEAR DISCRIMINANT-ANALYSIS
PREGNANCY
OUTCOMES
CHARTS
Publication Status
Published
Date Publish Online
2017-06-21