Non-invasive temporal interference electrical stimulation of the human hippocampus
File(s)
Author(s)
Type
Journal Article
Abstract
Deep brain stimulation (DBS) via implanted electrodes is used worldwide to treat patients with severe neurological and psychiatric disorders. However, its invasiveness precludes widespread clinical use and deployment in research. Temporal interference (TI) is a strategy for non-invasive steerable DBS using multiple kHz-range electric fields with a difference frequency within the range of neural activity. Here we report the validation of the non-invasive DBS concept in humans. We used electric field modeling and measurements in a human cadaver to verify that the locus of the transcranial TI stimulation can be steerably focused in the hippocampus with minimal exposure to the overlying cortex. We then used functional magnetic resonance imaging and behavioral experiments to show that TI stimulation can focally modulate hippocampal activity and enhance the accuracy of episodic memories in healthy humans. Our results demonstrate targeted, non-invasive electrical stimulation of deep structures in the human brain.
Date Issued
2023-11-01
Date Acceptance
2023-09-06
Citation
Nature Neuroscience, 2023, 26 (11), pp.1994-2004
ISSN
1097-6256
Publisher
Nature Research
Start Page
1994
End Page
2004
Journal / Book Title
Nature Neuroscience
Volume
26
Issue
11
Copyright Statement
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/37857775
PII: 10.1038/s41593-023-01456-8
Subjects
Humans
Brain
Hippocampus
Electric Stimulation
Cerebral Cortex
Electrodes, Implanted
Deep Brain Stimulation
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2023-10-19