Switchable genetic oscillator operating in quasi-stable mode
File(s)1071.full.pdf (627.2 KB)
Published version
Author(s)
Strelkowa, Natalja
Barahona, Mauricio
Type
Journal Article
Abstract
Ring topologies of repressing genes have qualitatively different long-term dynamics if the number of genes is odd (they oscillate) or even (they exhibit bistability). However, these attractors may not fully explain the observed behaviour in transient and stochastic environments such as the cell. We show here that even repressilators possess quasi-stable, travelling wave periodic solutions that are reachable, long-lived and robust to parameter changes. These solutions underlie the sustained oscillations observed in even rings in the stochastic regime, even if these circuits are expected to behave as switches. The existence of such solutions can also be exploited for control purposes: operation of the system around the quasi-stable orbit allows us to turn on and off the oscillations reliably and on demand. We illustrate these ideas with a simple protocol based on optical interference that can induce oscillations robustly both in the stochastic and deterministic regimes.
Date Issued
2010-07-06
Citation
JOURNAL OF THE ROYAL SOCIETY INTERFACE, 7, pp.{1071-1082}-{1071-1082}
ISSN
1742-5689
Publisher
ROYAL SOC
Start Page
{1071-1082}
End Page
{1071-1082}
Journal / Book Title
JOURNAL OF THE ROYAL SOCIETY INTERFACE
Volume
7
Issue
48
Copyright Statement
© 2010 The Royal Society. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
License URL
Description
29/11/14 meb. OA paper available will replace version.
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000277991600006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Publication Status
Published
Article Number
48