An integrated fluid-structure interaction and thrombosis model for type B aortic dissection
File(s)Chong2022_Article_AnIntegratedFluidStructureInte.pdf (7.04 MB)
Published version
Author(s)
Type
Journal Article
Abstract
False lumen thrombosis (FLT) in type B aortic dissection has been associated with the
progression of dissection and treatment outcome. Existing computational models mostly
assume rigid wall behaviour which ignores the effect of flap motion on flow and thrombus
formation within the FL. In this study, we have combined a fully coupled fluid-structure
interaction (FSI) approach with a shear-driven thrombosis model described by a series of
convection-diffusion reaction equations. The integrated FSI-thrombosis model has been
applied to an idealised dissection geometry to investigate the interaction between vessel wall
motion and growing thrombus. Our simulation results show that wall compliance and flap
motion can influence the progression of FLT. The main difference between the rigid and FSI
models is the continuous development of vortices near the tears caused by drastic flap motion
up to 4.45 mm. Flap-induced high shear stress and shear rates around tears help to transport
activated platelets further to the neighbouring region, thus speeding up thrombus formation
during the accelerated phase in the FSI models. Reducing flap mobility by increasing the
Young’s modulus of the flap slows down the thrombus growth. Compared to the rigid model,
the predicted thrombus volume is 25 % larger using the FSI-thrombosis model with a relatively
mobile flap. Furthermore, our FSI-thrombosis model can capture the gradual effect of thrombus
growth on the flow field, leading to flow obstruction in the FL, increased blood viscosity and
reduced flap motion. This model is a step closer towards simulating realistic thrombus growth
in aortic dissection, by taking into account the effect of intimal flap and vessel wall motion.
progression of dissection and treatment outcome. Existing computational models mostly
assume rigid wall behaviour which ignores the effect of flap motion on flow and thrombus
formation within the FL. In this study, we have combined a fully coupled fluid-structure
interaction (FSI) approach with a shear-driven thrombosis model described by a series of
convection-diffusion reaction equations. The integrated FSI-thrombosis model has been
applied to an idealised dissection geometry to investigate the interaction between vessel wall
motion and growing thrombus. Our simulation results show that wall compliance and flap
motion can influence the progression of FLT. The main difference between the rigid and FSI
models is the continuous development of vortices near the tears caused by drastic flap motion
up to 4.45 mm. Flap-induced high shear stress and shear rates around tears help to transport
activated platelets further to the neighbouring region, thus speeding up thrombus formation
during the accelerated phase in the FSI models. Reducing flap mobility by increasing the
Young’s modulus of the flap slows down the thrombus growth. Compared to the rigid model,
the predicted thrombus volume is 25 % larger using the FSI-thrombosis model with a relatively
mobile flap. Furthermore, our FSI-thrombosis model can capture the gradual effect of thrombus
growth on the flow field, leading to flow obstruction in the FL, increased blood viscosity and
reduced flap motion. This model is a step closer towards simulating realistic thrombus growth
in aortic dissection, by taking into account the effect of intimal flap and vessel wall motion.
Date Issued
2022-01-25
Date Acceptance
2021-10-11
Citation
Biomechanics and Modeling in Mechanobiology, 2022, 21, pp.261-275
ISSN
1617-7940
Publisher
Springer
Start Page
261
End Page
275
Journal / Book Title
Biomechanics and Modeling in Mechanobiology
Volume
21
Copyright Statement
© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
License URL
Sponsor
The Royal Society
Identifier
https://link.springer.com/article/10.1007/s10237-021-01534-5
Grant Number
NA170094
Subjects
Science & Technology
Life Sciences & Biomedicine
Technology
Biophysics
Engineering, Biomedical
Engineering
Aortic dissection (AD)
Fluid-structure interaction (FSI)
Computational fluid dynamics (CFD)
Intimal flap motion
Thrombus formation
FALSE LUMEN THROMBOSIS
INTRACRANIAL ANEURYSMS
COMPUTATIONAL MODEL
FLOW
IDENTIFICATION
HEMODYNAMICS
PREDICTION
REGIONS
Aortic dissection (AD)
Computational fluid dynamics (CFD)
Fluid–structure interaction (FSI)
Intimal flap motion
Thrombus formation
0903 Biomedical Engineering
0913 Mechanical Engineering
Biomedical Engineering
Publication Status
Published
Date Publish Online
2022-01-25