Mycobacterial growth
File(s)
Published version
Author(s)
Uhia, I
Williams, KJ
Shahrezaei, V
Robertson, BD
Type
Journal Article
Abstract
In this work, we review progress made in understanding the molecular underpinnings of growth and division in mycobacteria, concentrating on work published since the last comprehensive review ( Hett and Rubin 2008). We have focused on exciting work making use of new time-lapse imaging technologies coupled with reporter-gene fusions and antimicrobial treatment to generate insights into how mycobacteria grow and divide in a heterogeneous manner. We try to reconcile the different observations reported, providing a model of how they might fit together. We also review the topic of mycobacterial spores, which has generated considerable discussion during the last few years. Resuscitation promoting factors, and regulation of growth and division, have also been actively researched, and we summarize progress in these areas.
Date Issued
2015-05-08
Date Acceptance
2015-05-08
Citation
Cold Spring Harbor Perspectives in Medicine, 2015, 5 (10)
ISSN
2157-1422
Publisher
Cold Spring Harbor Laboratory Press
Journal / Book Title
Cold Spring Harbor Perspectives in Medicine
Volume
5
Issue
10
Copyright Statement
© 2015 Cold Spring Harbor Laboratory Press; all rights reserved
Sponsor
Imperial College Trust
Imperial College Trust
Grant Number
N/A
ICT/P52635/VS
Subjects
Science & Technology
Life Sciences & Biomedicine
Medicine, Research & Experimental
Research & Experimental Medicine
RESUSCITATION-PROMOTING FACTORS
RPF-LIKE GENES
SERINE/THREONINE PROTEIN-KINASE
CELL-WALL SYNTHESIS
CHROMOSOME SEGREGATION
BACTERIAL-GROWTH
CORYNEBACTERIUM-GLUTAMICUM
IN-VITRO
MULTIDRUG-RESISTANCE
ELECTRON-MICROSCOPY
Publication Status
Published
Article Number
a021097