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IgA1 glycosylation is heritable in healthy twins
File(s)
Author(s)
Lomax-Browne, HJ
Visconti, A
Pusey, CD
Spector, TD
Pickering, MC
Type
Journal Article
Abstract
IgA Nephropathy (IgAN) is the most common form of primary glomerulonephritis and an important cause of kidney failure. Characteristically, IgAN patients have increased serum levels of under-galactosylated IgA1 (gd-IgA1). We assessed the degree to which serum gd-IgA1 levels are genetically determined in healthy individuals. Serum IgA and gd-IgA1 level were determined by ELISA in a sample of 148 healthy female twins including 27 monozygotic and 47 dizygotic pairs. Using the classical twin model, the heritability of serum gd-IgA1 and IgA levels were 80% (95% CI: 66-89%) and 46% (95% CI: 15-69%) respectively. These data indicate that serum gd-IgA1 levels are highly heritable. Elucidating the genetic basis of this heritability will be important in understanding the pathogenesis of IgAN.
Date Issued
2017-01
Date Acceptance
2016-05-15
Citation
Journal of the American Society of Nephrology, 2017, 28 (1), pp.64-68
URI
URL
DOI
ISSN
1533-3450
Publisher
American Society of Nephrology
Start Page
64
End Page
68
Journal / Book Title
Journal of the American Society of Nephrology
Volume
28
Issue
1
Copyright Statement
© 2016 by the American Society of
Nephrology
Sponsor
King's College London
National Institute for Health Research
Identifier
https://jasn.asnjournals.org/content/28/1/64/
Grant Number
MR/K01353X/1
NF-SI-0611-10055
Subjects
Science & Technology
Life Sciences & Biomedicine
Urology & Nephrology
GENOME-WIDE ASSOCIATION
GALACTOSE-DEFICIENT IGA1
SUSCEPTIBILITY LOCI
RENAL-TRANSPLANTATION
IMMUNE-COMPLEXES
SWEDISH TWINS
HAN CHINESE
NEPHROPATHY
PATHOGENESIS
ANTIBODIES
IgA nephropathy
gd-IgA1
glycosylation
human genetics
Adult
Aged
Aged, 80 and over
Diseases in Twins
Female
Glomerulonephritis, IGA
Glycosylation
Humans
Immunoglobulin A
Middle Aged
Humans
Glomerulonephritis, IGA
Diseases in Twins
Immunoglobulin A
Glycosylation
Adult
Aged
Aged, 80 and over
Middle Aged
Female
1103 Clinical Sciences
Urology & Nephrology
Publication Status
Published
Date Publish Online
2016-12-30