Lesson of the month: novel method to quantify neutrophil uptake in early lung cancer using SPECT-CT.
File(s)1020.full.pdf (818.35 KB)
Published version
Author(s)
Type
Journal Article
Abstract
Neutrophils play an important role in the lung tumour microenvironment. We hypothesised that radiolabelled neutrophils coupled to single-photon emission CT (SPECT) may non-invasively quantify neutrophil uptake in tumours from patients with non-small cell lung cancer. We demonstrated increased uptake of radiolabelled neutrophils from the blood into tumours compared with non-specific uptake using radiolabelled transferrin. Moreover, indium-111-neutrophil activity in the tumour biopsies also correlated with myeloperoxidase (MPO)-positive neutrophils. Our data support the utility of imaging with In-111-labelled neutrophils and SPECT-CT to quantify neutrophil uptake in lung cancer.
Date Issued
2020-09-04
Date Acceptance
2020-07-14
ISSN
0040-6376
Publisher
BMJ Publishing Group
Start Page
1020
End Page
1023
Journal / Book Title
Thorax
Volume
75
Issue
11
Copyright Statement
© Author(s) (or their employer(s)) 2020. Re-use
permitted under CC BY. Published by BMJ
permitted under CC BY. Published by BMJ
Identifier
https://thorax.bmj.com/content/75/11/1020
https://www.ncbi.nlm.nih.gov/pubmed/32887739
thoraxjnl-2020-214642
Subjects
imaging/CT MRI etc
lung cancer
neutrophil biology
imaging/CT MRI etc
lung cancer
neutrophil biology
1103 Clinical Sciences
Respiratory System
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2020-09-04