Investigation into the presence of and serological response to XMRV in CFS patients
Author(s)
Type
Journal Article
Abstract
The novel human gammaretrovirus xenotropic murine leukemia virus-related virus (XMRV), originally described in prostate cancer, has also been implicated in chronic fatigue syndrome (CFS). When later reports failed to confirm the link to CFS, they were often criticised for not using the conditions described in the original study. Here, we revisit our patient cohort to investigate the XMRV status in those patients by means of the original PCR protocol which linked the virus to CFS. In addition, sera from our CFS patients were assayed for the presence of xenotropic virus envelope protein, as well as a serological response to it. The results further strengthen our contention that there is no evidence for an association of XMRV with CFS, at least in the UK.
Date Issued
2011-03-09
Date Acceptance
2011-01-26
Citation
PLOS One, 2011, 6 (3)
ISSN
1932-6203
Publisher
Public Library of Science
Journal / Book Title
PLOS One
Volume
6
Issue
3
Copyright Statement
© 2011 Erlwein et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
License URL
Subjects
Enzyme-linked immunoassays
Antibodies
Chronic fatigue syndrome
Serology
Polymerase chain reaction
Serum proteins
Recombinant proteins
Leukemias
Publication Status
Published
Article Number
e17592