Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure
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Published version
Author(s)
Type
Journal Article
Abstract
The skin’s tendency to sunburn rather than tan is a major risk factor for skin cancer. Here we report a large genome-wide association study of ease of skin tanning in 176,678 subjects of European ancestry. We identify significant association with tanning ability at 20 loci. We confirm previously identified associations at six of these loci, and report 14 novel loci, of which ten have never been associated with pigmentation-related phenotypes. Our results also suggest that variants at the AHR/AGR3 locus, previously associated with cutaneous malignant melanoma the underlying mechanism of which is poorly understood, might act on disease risk through modulation of tanning ability.
Date Issued
2018-05-08
Date Acceptance
2018-04-03
ISSN
2041-1723
Publisher
Nature Publishing Group
Start Page
1
End Page
7
Journal / Book Title
Nature Communications
Volume
9
Issue
1
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000431629600001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
SQUAMOUS-CELL CARCINOMA
SUSCEPTIBILITY LOCI
SKIN-CANCER
PIGMENTATION
MELANOMA
METAANALYSIS
TRAITS
COLOR
IDENTIFICATION
HAIR
MD Multidisciplinary
Publication Status
Published
Article Number
ARTN 1684
Date Publish Online
2018-05-08