Why are so many MLL lysine methyltransferases required for normal mammalian development?
Author(s)
Crump, Nicholas T
Milne, Thomas A
Type
Journal Article
Abstract
The mixed lineage leukemia (MLL) family of proteins became known initially for the leukemia link of its founding member. Over the decades, the MLL family has been recognized as an important class of histone H3 lysine 4 (H3K4) methyltransferases that control key aspects of normal cell physiology and development. Here, we provide a brief history of the discovery and study of this family of proteins. We address two main questions: why are there so many H3K4 methyltransferases in mammals; and is H3K4 methylation their key function?
Date Issued
2019-08-01
Date Acceptance
2019-05-10
Citation
Cellular and Molecular Life Sciences, 2019, 76 (15), pp.2885-2898
ISSN
1420-682X
Publisher
Springer
Start Page
2885
End Page
2898
Journal / Book Title
Cellular and Molecular Life Sciences
Volume
76
Issue
15
Copyright Statement
© The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
License URL
Identifier
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000476550200003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
Subjects
Biochemistry & Molecular Biology
BITHORAX COMPLEX
Cell Biology
COMPASS FAMILY
CPG ISLANDS
CXXC DOMAIN
Development
DROSOPHILA TRITHORAX GENE
Epigenetics
EXTRA-SEX-COMBS
H3K4
Histone
HISTONE H3
Life Sciences & Biomedicine
Methylation
MLL
POLYCOMB-GROUP
PROTO-ONCOPROTEIN MLL
Science & Technology
Transcription
TUMOR-SUPPRESSOR
Publication Status
Published
Date Publish Online
2019-05-16